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Browsing by Yonsei Author : Bok, Jin Woong

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Name :
Bok, Jin Woong [복진웅]
orcid http://orcid.org/0000-0003-1958-1872
Department :
College of Medicine (의과대학) - Dept. of Anatomy (해부학교실)
Scopus ID :
Scopus (25222398800)
Medical Student Research Advisor

교수 기본정보

세부 전공
인체발생학
이메일
bokj@yuhs.ac

실험실 기본정보

이름
Auditory Neuroscience Laboratory
위치
ABMRC 209
구분
Wet Lab (80%), Dry Lab (20%)
홈페이지
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연구소개

연구 분야
연구 내용
- 내이 발생학 (Cochlear Development) - 단순한 형태의 Otocyst가 복잡한 나선형 구조인 달팽이관으로 성숙하는 과정은 정교한 유전자 조절을 필요로 합니다. 본 연구실은 NGS 및 RNA 분석 기술을 활용하여 달팽이관의 발달 네트워크를 해독합니다.
- 주파수 감지 특성 및 정렬 (Tonotopic Organization) - 달팽이관은 기저부(Base)에서 고주파를, 첨부(Apex)에서 저주파를 감지하는 정교한 공간적-주파수 맵을 가집니다. 본 연구실은 달팽이관 형성 과정에서 이러한 주파수 정렬이 확립되는 분자적 기전을 추적합니다.
- 부동모 구조 및 아키텍처 (Stereociliary Architecture) - 청각 유모세포 상단의 부동모(Stereocilia)는 소리 진동을 전기 신호로 바꾸는 핵심 구조물입니다. 우리는 부동모 사이의 결합 구조와 정밀한 계단식 배열이 형성되는 원리를 연구하여, 구조적 결함에 의한 난청 치료 표적을 발굴합니다.
- 청각 장애 및 치료 (Hearing Loss & Therapeutics) - 청각은 단순한 감각을 넘어 소통과 정서적 안녕을 지탱하는 필수 기능입니다. 본 연구실은 노화, 소음, 유전 및 이독성 약물에 의한 난청의 근본적인 병리 기전을 연구하며, 이를 제어하기 위한 혁신적인 치료 전략을 수립합니다.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 사전 상담을 통해 현재 본 연구실에서 진행 중인 연구 주제 중 학생의 관심 분야에 부합하는 주제를 선정한 뒤, 지도교수의 지도 아래 해당 연구를 수행 중인 대학원생, 박사후연구원, 또는 연구교수와 긴밀히 협력하여 실질적인 연구를 진행하게 됨.
참여 전 준비사항
  • 실험동물부 이용자 교육 이수

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Researcher Network

Showing results 1 to 50 of 81

This table browses all dspace content
Issue DateTitleJournal Title
2025Antisense oligonucleotide therapy mitigates autosomal dominant progressive hearing loss in a murine model of human DFNA2 MOLECULAR THERAPY
2025SHANK2 establishes auditory hair bundle architecture essential for mammalian hearingPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2025Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction NATURE COMMUNICATIONS
2025Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated patterning of the cochlear ductDEVELOPMENTAL DYNAMICS
2025Biallelic variants of SEMA3F are associated with nonsyndromic hearing loss MOLECULES AND CELLS
2024Regenerative Role of Lrig1+ Cells in Kidney RepairJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2024MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss EXPERIMENTAL AND MOLECULAR MEDICINE
2023Alternative splicing in shaping the molecular landscape of the cochlea FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2023Hedgehog signaling regulates Wolffian duct development through the primary ciliumBIOLOGY OF REPRODUCTION
2023Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammalsPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2022Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2022Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia MOLECULAR BRAIN
2022Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model EBIOMEDICINE
2022Differential genetic diagnoses of adult post-lingual hearing loss according to the audiogram pattern and novel candidate gene evaluation HUMAN GENETICS
2021Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea FRONTIERS IN MOLECULAR BIOSCIENCES
2021Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking MOLECULES AND CELLS
2020Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models ELIFE
2020Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossiclesDEVELOPMENTAL DYNAMICS
2020A pathogen-derived metabolite induces microglial activation via odorant receptorsFEBS JOURNAL
2020CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear developmentDEVELOPMENTAL DYNAMICS
2020rMAPS2: an update of the RNA map analysis and plotting server for alternative splicing regulation NUCLEIC ACIDS RESEARCH
2020Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cellsPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2019Impact of miR-192 and miR-194 on Cyst Enlargement Through EMT in Autosomal Dominant Polycystic Kidney DiseaseFASEB JOURNAL
2019Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome EBIOMEDICINE
2019Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing THERANOSTICS
2019Targeted Gene Delivery into the Mammalian Inner Ear Using Synthetic Serotypes of Adeno-Associated Virus Vectors MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
2019Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency REDOX BIOLOGY
2019Region-specific endodermal signals direct neural crest cells to form the three middle ear ossiclesDEVELOPMENT
2018Expression patterns of Zfhx1a and Zfhx1b during mouse craniofacial development Korean Journal of Oral Anatomy (대한구강해부학회지)
2018Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte SCIENTIFIC REPORTS
2018Inhibition of the Zeb family prevents murine palatogenesis through regulation of apoptosis and the cell cycleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2018Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generationNEUROCHEMISTRY INTERNATIONAL
2018CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2018CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus MOLECULES AND CELLS
2018Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of HearingMOLECULAR NEUROBIOLOGY
2017Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
2017Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models SCIENTIFIC REPORTS
2017Spatiotemporal expression patterns of clusterin in the mouse inner earCELL AND TISSUE RESEARCH
2017Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencingGENE
2017Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysisCLINICAL IMMUNOLOGY
2016Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells.NANO LETTERS
2016Identification of a nonsense mutation in the STRC gene in a Korean family with moderate hearing loss.INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
2015Pannexin 3 is required for normal progression of skeletal development in vertebratesFASEB JOURNAL
2015Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2014Correlation between genotype and phenotype in patients with bi-allelic SLC26A4 mutationsCLINICAL GENETICS
2014The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss OPEN BIOLOGY
2014Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2014Developmental Changes of ENaC Expression and Function in the Inner Ear of Pendrin Knock-Out Mice as a Perspective on the Development of Endolymphatic Hydrops PLOS ONE
2014Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cellsHUMAN MOLECULAR GENETICS
2014Pax3 function is required specifically for inner ear structures with melanogenic fatesBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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