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CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development

Authors
 Harinarayana Ankamreddy  ;  Heiyeun Koo  ;  Young Jae Lee  ;  Jinwoong Bok 
Citation
 DEVELOPMENTAL DYNAMICS, Vol.249(9) : 1117-1126, 2020-09 
Journal Title
 DEVELOPMENTAL DYNAMICS 
ISSN
 1058-8388 
Issue Date
2020-09
Keywords
CXCL12 ; middle ear ; ossicle ; stapedial artery ; stapedial foramen ; stapes
Abstract
Background: The mammalian middle ear comprises a chain of three ossicles-the malleus, incus, and stapes-each of which has a unique morphology for efficiently transmitting sound information. In particular, the stapes, which is attached to the inner ear, is stirrup-shaped with a head and base connected by two crural arches, forming the stapedial foramen, through which the stapedial artery passes. However, how the stapes acquires this critical stirrup shape for association with the stapedial artery during development is not clear. Results: C-X-C motif chemokine ligand 12 (CXCL12) is a chemoattractant essential for cellular movement and angiogenesis. In Cxcl12 -/- embryos, migration of neural crest cells into the prospective middle ear regions and their mesenchymal condensation to form the three ossicles proceed normally in correct alignment with each other and the inner ear. However, in the absence of CXCL12, the stapes loses its stirrup shape and instead exhibits a columnar shape lacking the crural arches and central hole. In addition, although the stapedial artery initially forms during early mesenchymal condensation of the stapes, it degenerates without CXCL12 function. Conclusion: CXCL12 plays an essential role in establishing the stirrup-shaped architecture of the stapes, possibly by maintaining the stapedial foramen and stapedial artery throughout development.
Full Text
https://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.180
DOI
10.1002/dvdy.180
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Bok, Jin Woong(복진웅) ORCID logo https://orcid.org/0000-0003-1958-1872
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179982
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