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Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles

Authors
 Harinarayana Ankamreddy  ;  Jinwoong Bok  ;  Andrew K Groves 
Citation
 DEVELOPMENTAL DYNAMICS, Vol.249(12) : 1410-1424, 2020-10 
Journal Title
DEVELOPMENTAL DYNAMICS
ISSN
 1058-8388 
Issue Date
2020-10
Keywords
columella ; growth factors ; incus ; malleus ; middle ear ; neural crest cells ; ossicle ; stapes ; transcription factors
Abstract
The mammalian middle ear comprises a chain of ossicles, the malleus, incus, and stapes that act as an impedance matching device during the transmission of sound from the tympanic membrane to the inner ear. These ossicles are derived from cranial neural crest cells that undergo endochondral ossification and subsequently differentiate into their final functional forms. Defects that occur during middle ear development can result in conductive hearing loss. In this review, we summarize studies describing the crucial roles played by signaling molecules such as sonic hedgehog, bone morphogenetic proteins, fibroblast growth factors, notch ligands, and chemokines during the differentiation of neural crest into the middle ear ossicles. In addition to these cell-extrinsic signals, we also discuss studies on the function of transcription factor genes such as Foxi3, Tbx1, Bapx1, Pou3f4, and Gsc in regulating the development and morphology of the middle ear ossicles.
Full Text
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.260
DOI
10.1002/dvdy.260
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Bok, Jin Woong(복진웅) ORCID logo https://orcid.org/0000-0003-1958-1872
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182557
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