YUHSpace

BROWSE

YUHSpace

Browsing by Yonsei Author : Shin, Jeon Soo

eperson profile image
Name :
Shin, Jeon Soo [신전수]
orcid http://orcid.org/0000-0002-8294-3234
Department :
College of Medicine (의과대학) - Dept. of Microbiology (미생물학교실)
Scopus ID :
Scopus (7402724353)
Medical Student Research Advisor

교수 기본정보

세부 전공
감염 면역, 세포 죽음과 노화. 염증
이메일
jsshin6203@yuhs.ac

실험실 기본정보

이름
감염과 면역 실험실
위치
ABMRC 301호
구분
Wet Lab (100%), Dry Lab ( %)
홈페이지
홈페이지 바로가기

연구소개

연구 분야
연구 내용
면역계는 병원균 및 암 발생 억제에 중요한 역할을 담당하고 있다. 면역계는 선천면역(innate immunity)과 적응면역(adaptive immunity)으로 나누어지며 병원균의 pattern-associated molecular pattern(PAMP) 및 숙주 세포의 자극 혹은 죽음으로 유리되는 세포 단백(danger-associated molecular pattern, DAMP)이 숙주 수용체(pattern recognition receptor)와 결합하여 염증반응을 유발한다. 이러한 염증 반응은 급성 질환(패혈증 등) 및 만성 질환(대사성 질환, 암세포 전이, 자가면역질환, 노인성 신경질환, aging 등)의 병인과정을 이해하는 중요한 기전이다. 본 연구실은 염증기전에 근거한 위 급성 및 만성 질병 유발 기전, 염증에 따른 세포 노화 및 세포 죽음과 치료제 개발, 암세포 전이 기전을 연구하고 있다.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 위 주제에 따른 기본적인 연구계획서 작성 요령(연구멘토링), 연구 수행을 통해 기본적인 wet lab 연구 방법 습득 및 연구 수행을 습득하기 위한 그림자 밟기(심화연구멘토링) 및 실제 수행(연구집중과정).
학생 참여 시 사용하게 되는 장비 및 프로그램
  • 1. 실험에 따라 다양한 wet lab 장비, 분자생물학적 기법 이용을 통한 장비 활용: western blot, immunoprecipitation, confocal microscopy, flow cytometry, 단백질 정제, PCR, qRT-PCR, 세포 배양 관련 기법 등 실험에 맞는 다양한 장비 활용.
  • 2. 실험에 따라 동물실 이용
  • 3. 연구멘터링, 심화연구멘토링, 연구집중과정에 참여하게 되면 대학원생 혹은 연구교수와 배정되어 그림자 밟기 실습을 직접 참여하며, 실험실 랩미팅에 참여 가능함. 학생들에게 자율적인 기회를 제공하며 면담 후 결정함.
참여 전 준비사항
  • ▷ 실험실 안전관리교육 이수 (ABMRC 출입을 위한 교육 및 장비 활용 교육)
  • ▷ 실험동물부 이용자 교육 이수 (동물실 출입이 필요시)
  • ▷ 실험실 안전 교육 (한국연구재단의 기본 필수 요청사항 – 추후 문의 바람)

Keyword Cloud

Researcher Network

Showing results 1 to 50 of 146

This table browses all dspace content
Issue DateTitleJournal Title
2025Direct interaction of HMGB1 with SARS-CoV-2 facilitates its infection via RAGE-dependent endocytosis ISCIENCE
2025Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state METABOLISM-CLINICAL AND EXPERIMENTAL
2025Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer MOLECULAR MEDICINE
2025ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling REDOX BIOLOGY
2025Post-COVID-19 Effects on Chronic Gastritis and Gastric Cellular and Molecular Characteristics in Male Mice CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
2024Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progressionNATURE CANCER
2024Discovery of a new long COVID mouse model via systemic histopathological comparison of SARS-CoV-2 intranasal and inhalation infection BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
2024Super-resolution Surface Imaging of Live Cells with Sub-diffraction-limited Plasmonic NanospeckleProgress in Biomedical Optics and Imaging - Proceedings of SPIE
2024Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice IMMUNE NETWORK
2024A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice EBIOMEDICINE
2023SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs EXPERIMENTAL AND MOLECULAR MEDICINE
2023A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variantsANTIVIRAL RESEARCH
2023How Deep Learning in Antiviral Molecular Profiling Identified Anti-SARS-CoV-2 Inhibitors BIOMEDICINES
2023USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes FREE RADICAL BIOLOGY AND MEDICINE
2023Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitorsEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2023Sublingual Dissolving Microneedle (SLDMN)-Based Vaccine for Inducing Mucosal Immunity against SARS-CoV-2ADVANCED HEALTHCARE MATERIALS
2023A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections IMMUNE NETWORK
2023Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality AMERICAN JOURNAL OF PATHOLOGY
2023Establishment of multicenter COVID-19 therapeutics preclinical test system in Republic of Korea PULMONARY PHARMACOLOGY & THERAPEUTICS
2023SARS-CoV-2 Infection Induces HMGB1 Secretion Through Post-Translational Modification and PANoptosis IMMUNE NETWORK
2023SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model Laboratory Animal Research
2023Wide-field nanoscale imaging via near-field speckle illumination by nanoisland substratesProgress in Biomedical Optics and Imaging - Proceedings of SPIE
2022USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity MOLECULAR MEDICINE
2022Temporal Transcriptome Analysis of SARS-CoV-2-Infected Lung and Spleen in Human ACE2-Transgenic Mice MOLECULES AND CELLS
2022Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits FRONTIERS IN IMMUNOLOGY
2022Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models DISEASE MODELS & MECHANISMS
2022STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells CELL DEATH & DISEASE
2022Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice PLOS ONE
2022Laboratory information management system for COVID-19 non-clinical efficacy trial data Laboratory Animal Research
2022Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tailsJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2022Nanospeckle illumination microscopy via randomly localized near-field speckle by nanocomposite islandsProgress in Biomedical Optics and Imaging - Proceedings of SPIE
2022Disordered plasmonic substrate-based wide-field super-resolution imagingProgress in Biomedical Optics and Imaging - Proceedings of SPIE
2022Canagliflozin protects against cisplatin-induced acute kidney injury by AMPK-mediated autophagy in renal proximal tubular cells CELL DEATH DISCOVERY
2022Randomly localized plasmonic speckles by disordered nanoislands for super-resolution microscopyOptics InfoBase Conference Papers
2021In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2 BIOMEDICINES
2021Inflammasome-Dependent Peroxiredoxin 2 Secretion Induces the Classical Complement Pathway Activation IMMUNE NETWORK
2021Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion AUTOPHAGY
2021The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2 MOLECULAR MEDICINE
2021Disordered Nanocomposite Islands for Nanospeckle Illumination Microscopy in Wide-Field Super-Resolution ImagingADVANCED OPTICAL MATERIALS
2021Plasmon-enhanced fluorescence correlation spectroscopy for super-localized detection of nanoscale subcellular dynamicsBIOSENSORS & BIOELECTRONICS
2021Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage REDOX BIOLOGY
2021HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells CELL DEATH DISCOVERY
2020Editorial: The Role of HMGB1 in Immunity FRONTIERS IN IMMUNOLOGY
2020Electrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical isolates SCIENTIFIC REPORTS
2020Super-resolution image generation for improvement of orbital thin bone segmentationProceedings of SPIE--the International Society for Optical Engineering
2020Sulfatide Inhibits HMGB1 Secretion by Hindering Toll-Like Receptor 4 Localization Within Lipid Rafts FRONTIERS IN IMMUNOLOGY
2020Immunological Significance of HMGB1 Post-Translational Modification and Redox Biology FRONTIERS IN IMMUNOLOGY
2020Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers? BMC NEUROLOGY
2019Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus Annals of Child Neurology
2019Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus JOURNAL OF CLINICAL NEUROLOGY
123
  • License
    sherpa_romeo
    sherpa_juliet

OAK

DSpace Software Copyright © 2002-2017 Duraspace Yonsei University Medical Library All right Reserves. / TEL:02-2228-2915 /
YUHSpace는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Links