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Laboratory information management system for COVID-19 non-clinical efficacy trial data

 Suhyeon Yoon  ;  Hyuna Noh  ;  Heejin Jin  ;  Sungyoung Lee  ;  Soyul Han  ;  Sung-Hee Kim  ;  Jiseon Kim  ;  Jung Seon Seo  ;  Jeong Jin Kim  ;  In Ho Park  ;  Jooyeon Oh  ;  Joon-Yong Bae  ;  Gee Eun Lee  ;  Sun-Je Woo  ;  Sun-Min Seo  ;  Na-Won Kim  ;  Youn Woo Lee  ;  Hui Jeong Jang  ;  Seung-Min Hong  ;  Se-Hee An  ;  Kwang-Soo Lyoo  ;  Minjoo Yeom  ;  Hanbyeul Lee  ;  Bud Jung  ;  Sun-Woo Yoon  ;  Jung-Ah Kang  ;  Sang-Hyuk Seok  ;  Yu Jin Lee  ;  Seo Yeon Kim  ;  Young Been Kim  ;  Ji-Yeon Hwang  ;  Dain On  ;  Soo-Yeon Lim  ;  Sol Pin Kim  ;  Ji Yun Jang  ;  Ho Lee  ;  Kyoungmi Kim  ;  Hyo-Jung Lee  ;  Hong Bin Kim  ;  Jun Won Park  ;  Dae Gwin Jeong  ;  Daesub Song  ;  Kang-Seuk Choi  ;  Ho-Young Lee  ;  Yang-Kyu Choi  ;  Jung-Ah Choi  ;  Manki Song  ;  Man-Seong Park  ;  Jun-Young Seo  ;  Ki Taek Nam  ;  Jeon-Soo Shin  ;  Sungho Won  ;  Jun-Won Yun  ;  Je Kyung Seong 
 Laboratory Animal Research, Vol.38(1) : 17, 2022-06 
Journal Title
Laboratory Animal Research
Issue Date
COVID-19 ; Data ; Laboratory information management system ; Non-clinical ; SARS-CoV-2
Background: As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research.

Results: In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research.

Conclusions: This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies.
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung-Hee(김성희)
Nam, Ki Taek(남기택)
Park, Inho(박인호) ORCID logo https://orcid.org/0000-0003-2190-5469
Seo, Jun Young(서준영) ORCID logo https://orcid.org/0000-0003-4004-2013
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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