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A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections

Authors
 Gwanghee Kim  ;  Yoojin Lee  ;  Jin Sun You  ;  Wontae Hwang  ;  Jeewon Hwang  ;  Hwa Young Kim  ;  Jieun Kim  ;  Ara Jo  ;  In Ho Park  ;  Mohammed Ali  ;  Jongsun Kim  ;  Jeon-Soo Shin  ;  Ho-Keun Kwon  ;  Hyun Jik Kim  ;  Sang Sun Yoon 
Citation
 IMMUNE NETWORK, Vol.23(4) : e31, 2023-08 
Journal Title
IMMUNE NETWORK
ISSN
 1598-2629 
Issue Date
2023-08
Keywords
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) ; Human nasal microbiome ; Innate immune defense ; Staphylococcus epidermidis
Abstract
Evidence suggests that the human respiratory tract, as with the gastrointestinal tract, has evolved to its current state in association with commensal microbes. However, little is known about how the airway microbiome affects the development of airway immune system. Here, we uncover a previously unidentified mode of interaction between host airway immunity and a unique strain (AIT01) of Staphylococcus epidermidis, a predominant species of the nasal microbiome. Intranasal administration of AIT01 increased the population of neutrophils and monocytes in mouse lungs. The recruitment of these immune cells resulted in the protection of the murine host against infection by Pseudomonas aeruginosa, a pathogenic bacterium. Interestingly, an AIT01-secreted protein identified as GAPDH, a well-known bacterial moonlighting protein, mediated this protective effect. Intranasal delivery of the purified GAPDH conferred significant resistance against other Gram-negative pathogens (Klebsiella pneumoniae and Acinetobacter baumannii) and influenza A virus. Our findings demonstrate the potential of a native nasal microbe and its secretory protein to enhance innate immune defense against airway infections. These results offer a promising preventive measure, particularly relevant in the context of global pandemics.
Files in This Item:
T202307015.pdf Download
DOI
10.4110/in.2023.23.e31
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho-Keun(권호근) ORCID logo https://orcid.org/0000-0003-3175-0376
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Park, Inho(박인호) ORCID logo https://orcid.org/0000-0003-2190-5469
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Hwang, Wontae(황원태)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197373
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