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Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

Authors
 Sung-Won Cho ; Sungwook Kwak ; Han-Sung Jung ; Philip K. Maini ; Cheryll Tickle ; Jeon-Soo Shin ; Hee-Jin Kim ; Ruth E. Baker ; Eun-Jung Kim ; Min-Jung Lee ; Thomas E. Woolley 
Citation
 Development, Vol.138(9) : 1807~1816, 2011 
Journal Title
 Development 
ISSN
 0950-1991 
Issue Date
2011
Abstract
Each vertebrate species displays specific tooth patterns in each quadrant of the jaw: the mouse has one incisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of the key signaling molecules involved in the spatial patterning of teeth and other ectodermal organs such as hair, vibrissae and feathers. Sostdc1, a secreted inhibitor of the Wnt and Bmp pathways, also regulates the spatial patterning of teeth and hair. Here, by utilizing maternal transfer of 5E1 (an anti-Shh antibody) to mouse embryos through the placenta, we show that Sostdc1 is downstream of Shh signaling and suggest a Wnt-Shh-Sostdc1 negative feedback loop as a pivotal mechanism controlling the spatial patterning of teeth. Furthermore, we propose a new reaction-diffusion model in which Wnt, Shh and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse and can explain the various tooth patterns produced experimentally.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92801
DOI
10.1242/dev.056051
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
1. 연구논문 > 5. Research Institutes > Research Center for Orofacial Hard Tissue Regeneration
Yonsei Authors
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