YUHSpace

BROWSE

YUHSpace

Browsing by Yonsei Author : Song, Jae Jin

eperson profile image
Name :
Song, Jae Jin [송재진]
orcid http://orcid.org/0000-0001-8183-9550
Department :
College of Medicine (의과대학) - BioMedical Science Institute (의생명과학부)
Scopus ID :
Scopus (7404787442)
Medical Student Research Advisor

교수 기본정보

세부 전공
바이러스기반 암유전자 치료제 개발
이메일
JJS109@yuhs.ac

실험실 기본정보

이름
바이러스기반 종양치료 연구실
위치
임상의학연구센터 506호
구분
Wet Lab (100%), Dry Lab ( %)
홈페이지
홈페이지 바로가기

연구소개

연구 분야
연구 내용
바이러스 기반 종양치료연구실은 크게 3가지의 세분화된 연구를 수행한다. 첫째, 암세포신호전달 네트워크의 복잡성 이해를 통한 항암 치료유전자 후보군 발굴, 둘째, 아데노바이러스의 복제와 감염효율 증진에 관한 연구. 셋째, 실제 임상치료가 가능한 형태의 유전자 탑재된 암용해바이러스 기반 항암제 개발을 수행한다. 구체적으로 종양의 이질성과 항암제 내성 발달을 극복하기 위한 key targets 후보유전자 pool을 다수 확보하여 세포살상 및 면역능이 강화된 바이러스 기반 항암제 후보군들을 확립하고 효과를 검증하는 연구를 수행한다. 그리고 이들 후보물질들의 임상적 적용을 위해 암용해 바이러스(oncolytic virus, OV)의 체내 전달과 종양타겟팅을 위해 세포전달체 (중간엽줄기세포, MSC)의 최적화를 수행하고 궁극적으로는 OV/MSC 항암복합체 플랫폼 구축를 위한 연구를 진행한다.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 바이러스 제작 과정 및 마우스 항종양 실험
참여 전 준비사항
  • 실험동물부 이용자 교육 이수

Keyword Cloud

Researcher Network

Showing results 1 to 43 of 43

This table browses all dspace content
Issue DateTitleJournal Title
2025Combined downregulation of TGF-β1 and GRP78 is responsible for overcoming acquired sorafenib resistance, which is initiated by rewiring the cell surface CD44-GRP78-IGF-1R signaling circuit CANCER GENE THERAPY
2022Enhanced tumor targeting and timely viral release of mesenchymal stem cells/oncolytic virus complex due to GRP78 and inducible E1B55K expressions greatly increase the antitumor effect of systemic treatment MOLECULAR THERAPY-ONCOLYTICS
2021Enhanced oncolytic adenoviral production by downregulation of death-domain associated protein and overexpression of precursor terminal protein SCIENTIFIC REPORTS
2019High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication EXPERIMENTAL AND MOLECULAR MEDICINE
2018TGF-β downregulation-induced cancer cell death is finely regulated by the SAPK signaling cascade EXPERIMENTAL AND MOLECULAR MEDICINE
2018Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth GENOME RESEARCH
2017Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib. YONSEI MEDICAL JOURNAL
2017Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation ONCOTARGET
2016Survivin silencing and TRAIL expression using oncolytic adenovirus increase anti-tumorigenic activity in gemcitabine-resistant pancreatic cancer cellsAPOPTOSIS
2015Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrestCELLULAR SIGNALLING
2015Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cellsCELLULAR SIGNALLING
2014Establishment of a mouse melanoma model system for the efficient infection and replication of human adenovirus type 5-based oncolytic virusBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment: Inhibition of apoptosis by caspase degradation.CELLULAR SIGNALLING
2013The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagyINTERNATIONAL JOURNAL OF ONCOLOGY
2013c-Cbl shRNA-expressing adenovirus sensitizes TRAIL-induced apoptosis in prostate cancer DU-145 through increases of DR4/5CANCER GENE THERAPY
2013Transforming growth factor-β gene silencing using adenovirus expressing TGF-β1 or TGF-β2 shRNACANCER GENE THERAPY
2013TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complexCELLULAR SIGNALLING
2012HSP27 modulates survival signaling networks in cells treated with curcumin and TRAILCELLULAR SIGNALLING
2011MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation ONCOLOGY REPORTS
2011TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt INTERNATIONAL JOURNAL OF ONCOLOGY
2010c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment. CELLULAR SIGNALLING
2010c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance CELLULAR SIGNALLING
2008Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily CELLULAR SIGNALLING
2007Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance - Involvement of Bcl-xL JOURNAL OF BIOLOGICAL CHEMISTRY
2007Differential activation of the JNK signal pathway by UV irradiation and glucose deprivationCELLULAR SIGNALLING
2005Pretreatment of Acetylsalicylic Acid Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Down-regulating BCL-2 Gene Expression JOURNAL OF BIOLOGICAL CHEMISTRY
2005Cross-talk between JIP3 and JIP1 during Glucose Deprivation: SEK1-JNK2 and Akt1 act as mediators JOURNAL OF BIOLOGICAL CHEMISTRY
2005Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1–MEK–JNK signal transduction pathway during metabolic oxidative stress: A negative feedback loop JOURNAL OF CELL BIOLOGY
2005Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells CLINICAL CANCER RESEARCH
2004Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose deprivation JOURNAL OF BIOLOGICAL CHEMISTRY
2004Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathwayEXPERIMENTAL CELL RESEARCH
2004Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathwayJOURNAL OF CELLULAR BIOCHEMISTRY
2003Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization JOURNAL OF BIOLOGICAL CHEMISTRY
2003Catalase, but not MnSOD, inhibits glucose deprivation-activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: Hydrogen peroxide as a major second messenger of metabolic oxidative stressJOURNAL OF CELLULAR BIOCHEMISTRY
2003Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1 BIOCHEMICAL JOURNAL
2003Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of AktEXPERIMENTAL CELL RESEARCH
2003Effect of glucose concentration on activation of the ASK1–SEK1–JNK1 signal transduction pathwayJOURNAL OF CELLULAR BIOCHEMISTRY
2003dl-VSVG-LacZ, a VSV-G epitope incorporated adenoviurs exhibit marked enhancement in gene transduction efficiencyHUMAN GENE THERAPY
2003Optimization of vesicular stomatitis virus-G pseudotyped feline immunodeficiency virus vector for minimized cytotoxicity with efficient gene transferVIRUS RESEARCH
2002Role of glutaredoxin in metabolic oxidative stress - Glutaredoxin as a sensor of oxidative stress mediated by H2O2JOURNAL OF BIOLOGICAL CHEMISTRY
2002Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway MOLECULAR PHARMACOLOGY
2001Efficient gene transfer of VSV-G pseudotyped retroviral vector to human brain tumor GENE THERAPY
2000Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cellsCancer Letters
1
  • License
    sherpa_romeo
    sherpa_juliet

OAK

DSpace Software Copyright © 2002-2017 Duraspace Yonsei University Medical Library All right Reserves. / TEL:02-2228-2915 /
YUHSpace는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Links