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HSP27 modulates survival signaling networks in cells treated with curcumin and TRAIL.

Authors
 Jina Kim  ;  So Y. Kim  ;  Sujin Kang  ;  Hyo R. Yoon  ;  Bo K. Sun  ;  Dongxu Kang  ;  Joo-Hang Kim  ;  Jae J. Song 
Citation
 CELLULAR SIGNALLING, Vol.24(7) : 1444-1452, 2012 
Journal Title
 CELLULAR SIGNALLING 
ISSN
 0898-6568 
Issue Date
2012
MeSH
Apoptosis/drug effects* ; Cell Line, Tumor ; Cell Survival ; Curcumin/pharmacology* ; Drug Synergism ; HSP27 Heat-Shock Proteins/genetics ; HSP27 Heat-Shock Proteins/metabolism* ; Humans ; Oncogene Protein v-akt/genetics ; Oncogene Protein v-akt/metabolism* ; Phosphorylation/drug effects ; Protein Binding ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Small Interfering ; Receptors, Neuropeptide Y/metabolism ; Signal Transduction/drug effects* ; TNF Receptor-Associated Factor 6/genetics ; TNF Receptor-Associated Factor 6/metabolism ; TNF-Related Apoptosis-Inducing Ligand/pharmacology*
Keywords
TRAIL ; Curcumin ; HSP27 ; Akt ; PDK1 ; src ; PP1
Abstract
The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is not yet completely understood. In this study, we observed a close connection between dephosphorylated Akt and an increase in phosphorylated heat shock protein 27 (HSP27) during combined treatment with curcumin and TRAIL. Akt dephosphorylation was cumulatively regulated by protein phosphatase 1 (PP1), phosphoinositide-dependent kinase-1 (PDK1), and src. PP1 and PDK1 directly interacted with HSP27, whereas src indirectly interacted with HSP27 via the tumor necrosis factor receptor-associated factor 6 complex. In conclusion, HSP27 modulated cell survival by its interactions with various binding partners, depending on the level of phosphorylated HSP27.
Full Text
http://www.sciencedirect.com/science/article/pii/S0898656812000861
DOI
22449710
Appears in Collections:
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Song, Jae Jin(송재진) ORCID logo https://orcid.org/0000-0001-8183-9550
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89925
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