6 731

Cited 0 times in

HSP27 modulates survival signaling networks in cells treated with curcumin and TRAIL.

DC Field Value Language
dc.contributor.author김주항-
dc.contributor.author송재진-
dc.date.accessioned2014-12-19T16:38:52Z-
dc.date.available2014-12-19T16:38:52Z-
dc.date.issued2012-
dc.identifier.issn0898-6568-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89925-
dc.description.abstractThe combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is not yet completely understood. In this study, we observed a close connection between dephosphorylated Akt and an increase in phosphorylated heat shock protein 27 (HSP27) during combined treatment with curcumin and TRAIL. Akt dephosphorylation was cumulatively regulated by protein phosphatase 1 (PP1), phosphoinositide-dependent kinase-1 (PDK1), and src. PP1 and PDK1 directly interacted with HSP27, whereas src indirectly interacted with HSP27 via the tumor necrosis factor receptor-associated factor 6 complex. In conclusion, HSP27 modulated cell survival by its interactions with various binding partners, depending on the level of phosphorylated HSP27.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCELLULAR SIGNALLING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Survival-
dc.subject.MESHCurcumin/pharmacology*-
dc.subject.MESHDrug Synergism-
dc.subject.MESHHSP27 Heat-Shock Proteins/genetics-
dc.subject.MESHHSP27 Heat-Shock Proteins/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHOncogene Protein v-akt/genetics-
dc.subject.MESHOncogene Protein v-akt/metabolism*-
dc.subject.MESHPhosphorylation/drug effects-
dc.subject.MESHProtein Binding-
dc.subject.MESHProtein-Serine-Threonine Kinases/metabolism-
dc.subject.MESHRNA, Small Interfering-
dc.subject.MESHReceptors, Neuropeptide Y/metabolism-
dc.subject.MESHSignal Transduction/drug effects*-
dc.subject.MESHTNF Receptor-Associated Factor 6/genetics-
dc.subject.MESHTNF Receptor-Associated Factor 6/metabolism-
dc.subject.MESHTNF-Related Apoptosis-Inducing Ligand/pharmacology*-
dc.titleHSP27 modulates survival signaling networks in cells treated with curcumin and TRAIL.-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentInstitute for Cancer Research (암연구소)-
dc.contributor.googleauthorJina Kim-
dc.contributor.googleauthorSo Y. Kim-
dc.contributor.googleauthorSujin Kang-
dc.contributor.googleauthorHyo R. Yoon-
dc.contributor.googleauthorBo K. Sun-
dc.contributor.googleauthorDongxu Kang-
dc.contributor.googleauthorJoo-Hang Kim-
dc.contributor.googleauthorJae J. Song-
dc.identifier.doi22449710-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA02056-
dc.relation.journalcodeJ00502-
dc.identifier.eissn1873-3913-
dc.identifier.pmid22449710-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0898656812000861-
dc.subject.keywordTRAIL-
dc.subject.keywordCurcumin-
dc.subject.keywordHSP27-
dc.subject.keywordAkt-
dc.subject.keywordPDK1-
dc.subject.keywordsrc-
dc.subject.keywordPP1-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameSong, Jae Jin-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorSong, Jae Jin-
dc.citation.volume24-
dc.citation.number7-
dc.citation.startPage1444-
dc.citation.endPage1452-
dc.identifier.bibliographicCitationCELLULAR SIGNALLING, Vol.24(7) : 1444-1452, 2012-
dc.identifier.rimsid31981-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.