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c-Cbl shRNA-expressing adenovirus sensitizes TRAIL-induced apoptosis in prostate cancer DU-145 through increases of DR4/5

Authors
 S Y Kim ; J-H Kim ; J J Song 
Citation
 Cancer Gene Therapy, Vol.20(2) : 82~87, 2013 
Journal Title
 Cancer Gene Therapy 
ISSN
 0929-1903 
Issue Date
2013
Abstract
We previously demonstrated that the downregulation of Casitas B-lineage lymphoma (c-Cbl) can sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in two different ways. One way is to block the rapid degradation of TRAIL receptors, which can sustain TRAIL-induced apoptosis for a long time. Here, we designed a replication-defective adenovirus expressing the short hairpin RNA (shRNA) against c-Cbl to test the possibility of developing a cancer gene therapy that can act as a sensitizer of TRAIL. As expected from the results of our previous study that used a stable cell line with downregulated c-Cbl, infection with the c-Cbl shRNA-expressing adenovirus led to an increase in the death receptor 4 (DR4) and DR5 levels, which is known to be a cause for the increase of TRAIL-induced apoptosis. In conclusion, we demonstrated that c-Cbl shRNA-expressing adenovirus is able to sensitize TRAIL-induced apoptosis in vivo as well as in vitro.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86291
DOI
10.1038/cgt.2012.88
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Institute for Cancer Research
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.nature.com/cgt/journal/v20/n2/full/cgt201288a.html
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