7 279

Cited 0 times in

c-Cbl shRNA-expressing adenovirus sensitizes TRAIL-induced apoptosis in prostate cancer DU-145 through increases of DR4/5

Authors
 S Y Kim  ;  J-H Kim  ;  J J Song 
Citation
 Cancer Gene Therapy, Vol.20(2) : 82-87, 2013 
Journal Title
 Cancer Gene Therapy 
ISSN
 0929-1903 
Issue Date
2013
Abstract
We previously demonstrated that the downregulation of Casitas B-lineage lymphoma (c-Cbl) can sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in two different ways. One way is to block the rapid degradation of TRAIL receptors, which can sustain TRAIL-induced apoptosis for a long time. Here, we designed a replication-defective adenovirus expressing the short hairpin RNA (shRNA) against c-Cbl to test the possibility of developing a cancer gene therapy that can act as a sensitizer of TRAIL. As expected from the results of our previous study that used a stable cell line with downregulated c-Cbl, infection with the c-Cbl shRNA-expressing adenovirus led to an increase in the death receptor 4 (DR4) and DR5 levels, which is known to be a cause for the increase of TRAIL-induced apoptosis. In conclusion, we demonstrated that c-Cbl shRNA-expressing adenovirus is able to sensitize TRAIL-induced apoptosis in vivo as well as in vitro.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86291
DOI
10.1038/cgt.2012.88
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Cancer Research (암연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김주항(Kim, Joo Hang) ; 송재진(Song, Jae Jin)
사서에게 알리기
  feedback
Full Text
http://www.nature.com/cgt/journal/v20/n2/full/cgt201288a.html
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse