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The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy

Authors
 So Y. Kim  ;  Sujin Kang  ;  Jae J. Song  ;  Joo-Hang Kim 
Citation
 INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.42(4) : 1337-1348, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF ONCOLOGY 
ISSN
 1019-6439 
Issue Date
2013
MeSH
Adenoviridae/genetics* ; Antibiotics, Antineoplastic/pharmacology ; Autophagy* ; Cell Line, Tumor ; Cell Survival* ; Cytomegalovirus/genetics ; Genetic Vectors ; Humans ; Membrane Cofactor Protein/biosynthesis ; Membrane Cofactor Protein/genetics ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics* ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Recoverin/biosynthesis ; Recoverin/genetics ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Transduction, Genetic ; bcl-X Protein/metabolism
Keywords
Adenoviridae/genetics* ; Antibiotics, Antineoplastic/pharmacology ; Autophagy* ; Cell Line, Tumor ; Cell Survival* ; Cytomegalovirus/genetics ; Genetic Vectors ; Humans ; Membrane Cofactor Protein/biosynthesis ; Membrane Cofactor Protein/genetics ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics* ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Recoverin/biosynthesis ; Recoverin/genetics ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Transduction, Genetic ; bcl-X Protein/metabolism
Abstract
To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5̸F35 adenoviral vector did not exhibit any significant enhancement of transduction efficiency. CD46, a receptor for Ad35, was expressed in relatively small amounts in most of the cancer cells examined. Therefore, we investigated the pivotal factor(s) that render cancer cells susceptible to transduction. We discovered that the tumor transduction efficiency of Ad5/F35 was enhanced in the presence of rapamycin, an autophagy inducer, in some cancer cells. Analysis of survival potential and cell proliferation rates revealed that Ad5/F35 exerted a more pronounced oncolytic effect in cancer cells with higher survival potential in the presence of rapamycin.
Full Text
http://www.spandidos-publications.com/ijo/42/4/1337
DOI
10.3892/ijo.2013.1812
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Song, Jae Jin(송재진) ORCID logo https://orcid.org/0000-0001-8183-9550
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86423
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