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TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt

Authors
 BO K. SUN  ;  JOO-HANG KIM  ;  HOAN N. NGUYEN  ;  SO Y. KIM  ;  SEEUN OH  ;  YONG J. LEE  ;  JAE J. SONG 
Citation
 International Journal of Oncology, Vol.38(1) : 249-256, 2011 
Journal Title
 International Journal of Oncology 
ISSN
 1019-6439 
Issue Date
2011
Abstract
We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradation of TRAIL receptors and Akt phosphorylation during TRAIL treatment. Here, we show that Akt phosphorylation is not exclusively responsible for acquired TRAIL resistance. Akt catalytic activation is known to increase during metabolic oxidative stress, but we show that TRAIL also dramatically induces the catalytic activation of Akt in TRAIL-sensitive cells, but not in TRAIL-resistant cells. This suggests that Akt catalytic activation during TRAIL-induced apoptosis is likely to play a compensatory role in the maintenance of cell homeostasis. In addition, activated p38 and phosphorylated HSP27 were found to act as downstream effector molecules of p38 during TRAIL treatment and were shown to be responsible for increased Akt catalytic and invasive activities
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92569
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Cancer Research (암연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김소영(Kim, So Young) ; 김주항(Kim, Joo Hang) ; 선보경(Sun, Bo Kyung) ; 송재진(Song, Jae Jin) ; 오세은(Oh, Se Eun) ; 응구엔응옥호안(Nguyen, Hoan N.)
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