Cited 0 times in
TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김소영 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 선보경 | - |
dc.contributor.author | 송재진 | - |
dc.contributor.author | 오세은 | - |
dc.contributor.author | 응구엔응옥호안 | - |
dc.date.accessioned | 2014-12-20T16:21:34Z | - |
dc.date.available | 2014-12-20T16:21:34Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92569 | - |
dc.description.abstract | We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradation of TRAIL receptors and Akt phosphorylation during TRAIL treatment. Here, we show that Akt phosphorylation is not exclusively responsible for acquired TRAIL resistance. Akt catalytic activation is known to increase during metabolic oxidative stress, but we show that TRAIL also dramatically induces the catalytic activation of Akt in TRAIL-sensitive cells, but not in TRAIL-resistant cells. This suggests that Akt catalytic activation during TRAIL-induced apoptosis is likely to play a compensatory role in the maintenance of cell homeostasis. In addition, activated p38 and phosphorylated HSP27 were found to act as downstream effector molecules of p38 during TRAIL treatment and were shown to be responsible for increased Akt catalytic and invasive activities | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 249~256 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Caspases/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand/pharmacology* | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/genetics | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/metabolism* | - |
dc.title | TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | BO K. SUN | - |
dc.contributor.googleauthor | JOO-HANG KIM | - |
dc.contributor.googleauthor | HOAN N. NGUYEN | - |
dc.contributor.googleauthor | SO Y. KIM | - |
dc.contributor.googleauthor | SEEUN OH | - |
dc.contributor.googleauthor | YONG J. LEE | - |
dc.contributor.googleauthor | JAE J. SONG | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01933 | - |
dc.contributor.localId | A02378 | - |
dc.contributor.localId | A02636 | - |
dc.contributor.localId | A00621 | - |
dc.contributor.localId | A02056 | - |
dc.relation.journalcode | J01141 | - |
dc.identifier.eissn | 1791-2423 | - |
dc.identifier.pmid | 21109947 | - |
dc.subject.keyword | TRAIL | - |
dc.subject.keyword | p38 | - |
dc.subject.keyword | HSP27 | - |
dc.subject.keyword | Akt catalytic activity | - |
dc.subject.keyword | invasion | - |
dc.contributor.alternativeName | Kim, So Young | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Sun, Bo Kyung | - |
dc.contributor.alternativeName | Song, Jae Jin | - |
dc.contributor.alternativeName | Oh, Se Eun | - |
dc.contributor.alternativeName | Nguyen, Hoan N. | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Sun, Bo Kyung | - |
dc.contributor.affiliatedAuthor | Oh, Se Eun | - |
dc.contributor.affiliatedAuthor | Nguyen, Hoan N. | - |
dc.contributor.affiliatedAuthor | Kim, So Young | - |
dc.contributor.affiliatedAuthor | Song, Jae Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 256 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.38(1) : 249-256, 2011 | - |
dc.identifier.rimsid | 28638 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.