Browsing by Yonsei Author : Yoon, Ho Geun

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Name :
Yoon, Ho Geun [윤호근]
orcid http://orcid.org/0000-0003-2718-3372
Department :
College of Medicine (의과대학) - Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
Scopus ID :
Scopus (12797379300)

교수 기본정보

세부 전공
세포생물학
이메일
yhgeun@yuhs.ac

실험실 기본정보

이름
윤호근 실험실
위치
ABMRC 418호
구분
Wet Lab (100%), Dry Lab ( %)

연구소개

연구 분야
연구 내용
▷ 섬유화는 조직의 손상과 치유과정에서 collagen이나 fibronectin과 같은 섬유성결합물질이 과도하게 축적되어 정상 조직을 파괴하여 기능의 장애를 가져옴. 폐, 신장, 간에서 주로 발병하는 것이 알려져 있으며, 섬유화 질환은 현재까지도 발병원인과 근본적인 치료방법이 없어 세계적으로 미충족 의료수요가 매우 큰 질병이며 이러한 중요성으로 섬유화 관련 질환을 타겟하는 신약은 미국 FDA에서 혁신신약으로 지정되어 신속한 허가가 이루어 지고 있음. 섬유화의 원인인 상피세포의 손상은 다양한 유전적‧환경적 원인에 의해 시간이 지나면서 축적되어 일어나는 것으로 알려져 있음. 이러한 원인들이 축적되어 질환이 유발될 때 섬유화 유전자들의 비정상적 발현변화를 일으키는데, 이때 후성유전학 조절 효소들이 관여할 것으로 예상됨. 그러나 현재 특정 조직의 섬유화에 있어 유전적인 프로파일링이나 당뇨병/고혈압 같은 병적 요인에 따른 유전자 발현에 관한 연구들은 많이 연구되어 왔으나, 질환의 진행에 있어 후성유전적인 접근 연구는 상대적으로 미진한 상태임.
▷ 본 연구팀은 폐, 신장 및 간 섬유화에서의 연구결과에서 후성유전학효소들의 기능이상은 섬유화발달로 이어짐을 규명하였으며, 최근 국제공동연구를 통해서도 자궁섬유화의 원인도 히스톤 아세틸화효소 (p300)와 탈아세틸화효소 (HDAC3) 간의 가역적 전사조절의 불균형이 콜라겐의 과도한 발현을 유도하여 자궁섬유화와 자궁내막증을 유발한다는 것을 발표하였음. 따라서 후성유전학적 불균형의 제어를 할 수 있는 분자기전/표적의 규명은 향후 새로운 조직섬유화 질환 치료법 개발로 이어질 수 있을 것으로 가정하고 다양한 세포, GEM 마우스 모델과 Epigenetic drug (Epidrug)을 이용하여 섬유화질환 유발과 관련된 후성유전학적 조절네트워크 규명 및 이를 조절하는 치료법 개발 연구를 수행하고 있음.

학생 참여 정보

학생들이 참여하면 좋을 연구
  • 폐섬유화 유발 관련 신규 후성유전학적 조절 분자네트워크 선별 및 이의 검증으로서 특발성 폐섬유화 환자 특이적 과발현 단백질로 알려진 히스톤아세틸화 효소 P300에 대한 결합단백질들 (이미 실험실에서 후보단백질들 선별완료하였음)에 대해 폐섬유화 유도 시 실제 결합여부 검증과 KO 유전자 조작 마우스와 IPF 환자조직 및 Single cell RNA Seq 데이터베이스를 기반으로 한 임상학적 연관성 규명)
학생 참여 시 사용하게 되는 장비 및 프로그램
  • Quantitative RT-PCR, Confocal microscope, Western blot용 RAS 이미지장치, Cell culture, 동물실 등등
참여 전 준비사항
  • 실험동물부 이용자 교육 이수, 질병관리청 온라인교육 이수, IRB 교육 이수

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Showing results 1 to 50 of 117

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Issue DateTitleJournal Title
2025Plumbagin ameliorates renal fibrosis by suppressing epithelial-mesenchymal transitionBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2025JMJD4 promotes tumor progression via inhibition of the PDCD5-TP53 pathway BMB REPORTS
2024Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stabilityBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2024Generation of an induced pluripotent stem cell line from a patient with arrhythmogenic right ventricular cardiomyopathy harboring a TMEM43 splice-site variant STEM CELL RESEARCH
2024Inhibition of TBL1 cleavage alleviates doxorubicin-induced cardiomyocytes death by regulating the Wnt/β-catenin signal pathway CARDIOVASCULAR RESEARCH
2023Water Extract of Capsella bursa-pastoris Mitigates Doxorubicin-Induced Cardiotoxicity by Upregulating Antioxidant Enzymes INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2023The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis EXPERIMENTAL AND MOLECULAR MEDICINE
2023Therapeutic effects of selective p300 histone acetyl-transferase inhibitor on liver fibrosis BMB REPORTS
2022Epigenetic regulator Cfp1 safeguards male meiotic progression by regulating meiotic gene expression EXPERIMENTAL AND MOLECULAR MEDICINE
2022Fermented Curcuma longa L. Prevents Alcoholic Fatty Liver Disease in Mice by Regulating CYP2E1, SREBP-1c, and PPAR- αJOURNAL OF MEDICINAL FOOD
2022Loss of MIG-6 results in endometrial progesterone resistance via ERBB2 NATURE COMMUNICATIONS
2022Generation of a human induced pluripotent stem cell line YCMi004-A from a patient with dilated cardiomyopathy carrying a protein-truncating mutation of the Titin gene and its differentiation towards cardiomyocytes STEM CELL RESEARCH
2022Beneficial Effects of a Combination of Curcuma longa L. and Citrus junos Against Beta-Amyloid Peptide-Induced Neurodegeneration in MiceJOURNAL OF MEDICINAL FOOD
2021Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His STEM CELL RESEARCH
2021Water Extract of Rubus coreanus Prevents Inflammatory Skin Diseases In Vitro Models PLANTS-BASEL
2021Club cell-specific role of programmed cell death 5 in pulmonary fibrosis NATURE COMMUNICATIONS
2021Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory ActivityJOURNAL OF MEDICINAL FOOD
2020Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agentCHEMICAL COMMUNICATIONS
2020Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase ActivityJOURNAL OF MEDICINAL FOOD
2019EGFR-c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells CELLS(Cells)
2019AmeliorativeEffectsofDendropanaxmorbiferaon Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression inβ-Amyloid-Induced MiceJOURNAL OF MEDICINAL FOOD
2019EPB41L5 Mediates TGFβ-Induced Metastasis of Gastric CancerCLINICAL CANCER RESEARCH
2019Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.JOURNAL OF CELLULAR PHYSIOLOGY
2019Tyrosine phosphorylation of HDAC3 by Src kinase mediates proliferation of HER2-positive breast cancer cellsJOURNAL OF CELLULAR PHYSIOLOGY
2019GPR177 promotes gastric cancer proliferation by suppressing endoplasmic reticulum stress‐induced cell deathJOURNAL OF CELLULAR BIOCHEMISTRY
2019Loss of HDAC3 results in nonreceptive endometrium and female infertilitySCIENCE TRANSLATIONAL MEDICINE
2018Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis BMB REPORTS
2018Programmed cell death 5 suppresses AKT-mediated cytoprotection of endotheliumPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2017Gender Difference in the Long-Term Clinical Implications of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting YONSEI MEDICAL JOURNAL
2017Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5 SCIENTIFIC REPORTS
2016Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells ONCOTARGET
2016SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth. ONCOTARGET
2016Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPKCLINICAL NUTRITION
2015Glucose deprivation triggers protein kinase C-dependent β-catenin proteasomal degradation JOURNAL OF BIOLOGICAL CHEMISTRY
2015DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signalingBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2015Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response NATURE COMMUNICATIONS
2015Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage. ONCOTARGET
2015Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's diseaseINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2015YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2015PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell deathHUMAN MOLECULAR GENETICS
2015Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stressCANCER LETTERS
2015DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosisCANCER LETTERS
2014Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammationJOURNAL OF ALZHEIMERS DISEASE
2014Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activationCANCER RESEARCH
2014High mobility group nucleosomal binding domain 2 (HMGN2) sumoylation by the SUMO E3 ligase PIAS1 decreases the binding affinity to nucleosome core particlesJOURNAL OF BIOLOGICAL CHEMISTRY
2013Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cellsJOURNAL OF CELLULAR PHYSIOLOGY
2013Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity miceSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
2013Reduction of the CD16(-)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer PLOS ONE
2013CK2-NCoR signaling cascade promotes prostate tumorigenesis ONCOTARGET
2013Selective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicityINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

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