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Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory Activity

Authors
 Soo Yeon Lee  ;  Soo-Yeon Park  ;  Gyeong-Eun Lee  ;  Hyunsik Kim  ;  Jae-Hwan Kwon  ;  Mi Jeong Kim  ;  Ho-Geun Yoon 
Citation
 JOURNAL OF MEDICINAL FOOD, Vol.24(2) : 151-160, 2021-02 
Journal Title
 JOURNAL OF MEDICINAL FOOD 
ISSN
 1096-620X 
Issue Date
2021-02
MeSH
Animals ; Anti-Inflammatory Agents / pharmacology ; Anti-Inflammatory Agents / therapeutic use ; Bleomycin* ; Disease Models, Animal ; Fibroblasts / drug effects ; Idiopathic Pulmonary Fibrosis* / chemically induced ; Idiopathic Pulmonary Fibrosis* / drug therapy ; Idiopathic Pulmonary Fibrosis* / genetics ; Lung / drug effects ; Macrophages / drug effects ; Mice ; Mice, Inbred C57BL ; Sesquiterpenes* / pharmacology
Keywords
aucuparin ; bleomycin ; inflammation ; pulmonary fibrosis
Abstract
Idiopathic pulmonary fibrosis (IPF) is a lung disease that results in scarring of the lungs for an unknown reason. Although many studies have been conducted on IPF, precise mechanisms and treatments have not yet been identified. In this study, we found that aucuparin, a natural product isolated from Sorbus aucuparia, inhibited pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. In the lung samples of mice treated with aucuparin, the gene expression of inflammation and macrophage activation markers was reduced compared to those treated with BLM alone. Moreover, aucuparin decreased the expression of profibrotic marker genes and increased the expression of antifibrotic marker genes. Finally, we observed that aucuparin significantly suppressed transforming growth factor-β-induced activation of inflammatory cytokine production and collagen synthesis from macrophages and fibroblasts, respectively. Taken together, these data demonstrate that aucuparin inhibits lung fibrosis via its anti-inflammatory action and support its potential to be a therapeutic drug for IPF treatment.
Full Text
https://www.liebertpub.com/doi/10.1089/jmf.2020.4861
DOI
10.1089/jmf.2020.4861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Jeong(김미정) ORCID logo https://orcid.org/0000-0002-0758-7145
Park, Soo Yeon(박수연) ORCID logo https://orcid.org/0000-0003-3743-9554
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182188
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