141 354

Cited 0 times in

Generation of a human induced pluripotent stem cell line YCMi004-A from a patient with dilated cardiomyopathy carrying a protein-truncating mutation of the Titin gene and its differentiation towards cardiomyocytes

 Sun-Ho Lee  ;  Jaewon Oh  ;  Seung-Tae Lee  ;  Dongju Won  ;  Sangwoo Kim  ;  Hyo-Kyoung Choi  ;  Seok-Jun Kim  ;  Hyunho Han  ;  Minjae Yoon  ;  Jong Rak Choi  ;  Ho-Geun Yoon  ;  Sahng Wook Park  ;  Seok-Min Kang  ;  Seung-Hyun Lee 
 STEM CELL RESEARCH, Vol.59 : 102629, 2022-03 
Journal Title
Issue Date
Dilated cardiomyopathy (DCM) is a heart muscle disease that causes heart failure and is the leading cause for heart transplantation. It is a heart muscle disease resulted from a variety of genetics, toxic, metabolic, and infectious causes. One of the most prevalent genetic causes of DCM is a protein-truncating variant in the Titin gene (TTNtv). We have generated a human-induced pluripotent stem cell (hiPSC) line from patients who underwent heart transplantation due to DCM carrying a TTNtv mutation (c.70051C > T, p.Arg23351Ter) at the age of 20. The generated hiPSCs showed normal karyotype (46, XY) and expression of pluripotency markers, and were differentiated towards cardiomyocytes successfully.
Files in This Item:
T202200556.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sangwoo(김상우) ORCID logo https://orcid.org/0000-0001-5356-0827
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Won, Dongju(원동주) ORCID logo https://orcid.org/0000-0002-0084-0216
Yoon, Minjae(윤민재)
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
Lee, Seung Hyun(이승현) ORCID logo https://orcid.org/0000-0001-7549-9430
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
Han, Hyun Ho(한현호) ORCID logo https://orcid.org/0000-0002-6268-0860
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.