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CK2-NCoR signaling cascade promotes prostate tumorigenesis

Authors
 Jung-Yoon Yoo  ;  Beom Jin Lim  ;  Hyo-Kyoung Choi  ;  Soon Won Hong  ;  Ho Sung Jang  ;  Changsoo Kim  ;  Kyung-Hee Chun  ;  Kyung-Chul Choi  ;  Ho-Geun Yoon 
Citation
 ONCOTARGET , Vol.4(7) : 972-983, 2013 
Journal Title
 ONCOTARGET 
Issue Date
2013
MeSH
Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism* ; Casein Kinase II/metabolism* ; Cell Line, Tumor ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism* ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mice, Transgenic ; Neoplasm Invasiveness ; Phosphorylation ; Prostatic Neoplasms/metabolism* ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; Signal Transduction ; Tumor Cells, Cultured
Keywords
CK2α ; NCoR ; Prostate cancer ; IP-10 ; transcriptional regulation
Abstract
The aberrant expressions of casein kinase 2 (CK2) was found in prostate cancer patient and cell lines, but little is known of the detailed mechanisms implicated in prostate tumorigenesis. In this study, we report that both CK2 activity and CK2-mediated NCoR phosphorylation are significantly elevated in the androgen-independent prostate cancer cell line DU145 and PC-3 compared with RWPE1 and LNCaP cells. Increased phosphorylation inversely correlates with the mRNA level of the NCoR-regulated gene, interferon-γ-inducible protein 10 (IP-10). CK2 inhibition abrogated NCoR phosphorylation, IP-10 transcriptional repression, and the invasion activity of PC-3 cells. Inhibition of the CK2-NCoR network significantly reduced in vivo PC-3 cell tumorigenicity, likely due to transcriptional derepression of IP-10. Clinicopathological analyses revealed that increased CK2-mediated NCoR phosphorylation significantly correlates with poor survival among prostate cancer patients. These findings elucidate a CK2-modulated oncogenic cascade in prostate tumorigenesis.
Files in This Item:
T201302141.pdf Download
DOI
23669876
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Yoo, Jung Yoon(유정윤) ORCID logo https://orcid.org/0000-0001-9366-3863
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Chun, Kyung Hee(전경희) ORCID logo https://orcid.org/0000-0002-9867-7321
Choi, Hyo Kyoung(최효경)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87191
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