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CK2-NCoR signaling cascade promotes prostate tumorigenesis

DC Field Value Language
dc.contributor.author김창수-
dc.contributor.author윤호근-
dc.contributor.author임범진-
dc.contributor.author전경희-
dc.contributor.author최효경-
dc.contributor.author홍순원-
dc.contributor.author유정윤-
dc.date.accessioned2014-12-18T08:55:05Z-
dc.date.available2014-12-18T08:55:05Z-
dc.date.issued2013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87191-
dc.description.abstractThe aberrant expressions of casein kinase 2 (CK2) was found in prostate cancer patient and cell lines, but little is known of the detailed mechanisms implicated in prostate tumorigenesis. In this study, we report that both CK2 activity and CK2-mediated NCoR phosphorylation are significantly elevated in the androgen-independent prostate cancer cell line DU145 and PC-3 compared with RWPE1 and LNCaP cells. Increased phosphorylation inversely correlates with the mRNA level of the NCoR-regulated gene, interferon-γ-inducible protein 10 (IP-10). CK2 inhibition abrogated NCoR phosphorylation, IP-10 transcriptional repression, and the invasion activity of PC-3 cells. Inhibition of the CK2-NCoR network significantly reduced in vivo PC-3 cell tumorigenicity, likely due to transcriptional derepression of IP-10. Clinicopathological analyses revealed that increased CK2-mediated NCoR phosphorylation significantly correlates with poor survival among prostate cancer patients. These findings elucidate a CK2-modulated oncogenic cascade in prostate tumorigenesis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinogenesis/genetics-
dc.subject.MESHCarcinogenesis/metabolism*-
dc.subject.MESHCasein Kinase II/metabolism*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCo-Repressor Proteins/genetics-
dc.subject.MESHCo-Repressor Proteins/metabolism*-
dc.subject.MESHHeterografts-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPhosphorylation-
dc.subject.MESHProstatic Neoplasms/metabolism*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHProstatic Neoplasms, Castration-Resistant/metabolism-
dc.subject.MESHProstatic Neoplasms, Castration-Resistant/pathology-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTumor Cells, Cultured-
dc.titleCK2-NCoR signaling cascade promotes prostate tumorigenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorJung-Yoon Yoo-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorHyo-Kyoung Choi-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorHo Sung Jang-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorKyung-Hee Chun-
dc.contributor.googleauthorKyung-Chul Choi-
dc.contributor.googleauthorHo-Geun Yoon-
dc.identifier.doi23669876-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01042-
dc.contributor.localIdA02625-
dc.contributor.localIdA03363-
dc.contributor.localIdA03501-
dc.contributor.localIdA04225-
dc.contributor.localIdA04411-
dc.contributor.localIdA02502-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid23669876-
dc.subject.keywordCK2α-
dc.subject.keywordNCoR-
dc.subject.keywordProstate cancer-
dc.subject.keywordIP-10-
dc.subject.keywordtranscriptional regulation-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameChun, Kyung Hee-
dc.contributor.alternativeNameChoi, Hyo Kyoung-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Chang Soo-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorChun, Kyung Hee-
dc.contributor.affiliatedAuthorChoi, Hyo Kyoung-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.contributor.affiliatedAuthorYoo, Jung Yoon-
dc.contributor.affiliatedAuthor유정윤-
dc.rights.accessRightsfree-
dc.citation.volume4-
dc.citation.number7-
dc.citation.startPage972-
dc.citation.endPage983-
dc.identifier.bibliographicCitationONCOTARGET , Vol.4(7) : 972-983, 2013-
dc.identifier.rimsid32548-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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