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CK2-NCoR signaling cascade promotes prostate tumorigenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창수 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 전경희 | - |
dc.contributor.author | 최효경 | - |
dc.contributor.author | 홍순원 | - |
dc.contributor.author | 유정윤 | - |
dc.date.accessioned | 2014-12-18T08:55:05Z | - |
dc.date.available | 2014-12-18T08:55:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87191 | - |
dc.description.abstract | The aberrant expressions of casein kinase 2 (CK2) was found in prostate cancer patient and cell lines, but little is known of the detailed mechanisms implicated in prostate tumorigenesis. In this study, we report that both CK2 activity and CK2-mediated NCoR phosphorylation are significantly elevated in the androgen-independent prostate cancer cell line DU145 and PC-3 compared with RWPE1 and LNCaP cells. Increased phosphorylation inversely correlates with the mRNA level of the NCoR-regulated gene, interferon-γ-inducible protein 10 (IP-10). CK2 inhibition abrogated NCoR phosphorylation, IP-10 transcriptional repression, and the invasion activity of PC-3 cells. Inhibition of the CK2-NCoR network significantly reduced in vivo PC-3 cell tumorigenicity, likely due to transcriptional derepression of IP-10. Clinicopathological analyses revealed that increased CK2-mediated NCoR phosphorylation significantly correlates with poor survival among prostate cancer patients. These findings elucidate a CK2-modulated oncogenic cascade in prostate tumorigenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinogenesis/genetics | - |
dc.subject.MESH | Carcinogenesis/metabolism* | - |
dc.subject.MESH | Casein Kinase II/metabolism* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Co-Repressor Proteins/genetics | - |
dc.subject.MESH | Co-Repressor Proteins/metabolism* | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Prostatic Neoplasms/metabolism* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms, Castration-Resistant/metabolism | - |
dc.subject.MESH | Prostatic Neoplasms, Castration-Resistant/pathology | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | CK2-NCoR signaling cascade promotes prostate tumorigenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Jung-Yoon Yoo | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Hyo-Kyoung Choi | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Ho Sung Jang | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Kyung-Hee Chun | - |
dc.contributor.googleauthor | Kyung-Chul Choi | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.identifier.doi | 23669876 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03501 | - |
dc.contributor.localId | A04225 | - |
dc.contributor.localId | A04411 | - |
dc.contributor.localId | A02502 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 23669876 | - |
dc.subject.keyword | CK2α | - |
dc.subject.keyword | NCoR | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | IP-10 | - |
dc.subject.keyword | transcriptional regulation | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Chun, Kyung Hee | - |
dc.contributor.alternativeName | Choi, Hyo Kyoung | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Chun, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Choi, Hyo Kyoung | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Yoo, Jung Yoon | - |
dc.contributor.affiliatedAuthor | 유정윤 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 4 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 972 | - |
dc.citation.endPage | 983 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.4(7) : 972-983, 2013 | - |
dc.identifier.rimsid | 32548 | - |
dc.type.rims | ART | - |
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