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Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.

Authors
 Sungmin Kwak  ;  Seung‐Hyun Lee  ;  Eun‐Jung Han  ;  Soo‐Yeon Park  ;  Mi‐Hyeon Jeong  ;  Jaesung Seo  ;  Seung‐Ho Park  ;  Gi‐Jun Sung  ;  Jung‐Yoon Yoo  ;  Ho‐Geun Yoon  ;  Kyung‐Chul Choi 
Citation
 Journal of Cellular Physiology, Vol.234(3) : 2649-2658, 2019 
Journal Title
 Journal of Cellular Physiology 
ISSN
 0021-9541 
Issue Date
2019
Keywords
PDCD5 ; STK31 ; apoptosis ; colon cancer ; p53
Abstract
Although programed cell death 5 (PDCD5) is an important protein in p53-mediated proapoptotic signaling, very little is known about PDCD5-related cell death. In this study, we report that serine/threonine kinase 31 (STK31) interacts with PDCD5, which maintains the stability of PDCD5. STK31 overexpression significantly activated PDCD5 stabilization and p53-mediated apoptosis in response to etoposide (ET). However, STK31 knockdown did not enhance apoptosis by ET treatment. Moreover, when STK31 was depleted, PDCD5 inhibited the activation of the p53 signaling pathway with ET, indicating that the PDCD5-STK31 network has an essential role in p53 activation. Importantly, STK31 activated the p53 signaling pathway by genotoxic stress through positive regulation of PDCD5-mediated apoptosis. We thus demonstrated that overexpression of STK31 greatly inhibited tumorigenic growth and increased the chemosensitivity of HCT116 human colorectal carcinoma cells. Taken together, these findings demonstrate that the STK31-PDCD5 complex network regulates apoptosis of cancer cells, and STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.27079
DOI
10.1002/jcp.27079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
박수연(Park, Soo Yeon) ORCID logo https://orcid.org/0000-0003-3743-9554
유정윤(Yoo, Jung Yoon) ORCID logo https://orcid.org/0000-0001-9366-3863
윤호근(Yoon, Ho Geun) ORCID logo https://orcid.org/0000-0003-2718-3372
이승현(Lee, Seung Hyun) ORCID logo https://orcid.org/0000-0001-7549-9430
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167562
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