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Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

Authors
 Jaewon Oh  ;  Sun-Ho Lee  ;  Jungyoon Choi  ;  Jong Rak Choi  ;  Sangwoo Kim  ;  Yun-Ji Cha  ;  Hyo-Kyoung Choi  ;  Dongju Won  ;  Ho-Geun Yoon  ;  Sahng Wook Park  ;  Seok-Min Kang  ;  Seung-Tae Lee  ;  Seung-Hyun Lee 
Citation
 STEM CELL RESEARCH, Vol.56 : 102508, 2021-10 
Journal Title
STEM CELL RESEARCH
ISSN
 1873-5061 
Issue Date
2021-10
Abstract
Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.
Files in This Item:
T202103883.pdf Download
DOI
10.1016/j.scr.2021.102508
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sangwoo(김상우) ORCID logo https://orcid.org/0000-0001-5356-0827
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Won, Dongju(원동주) ORCID logo https://orcid.org/0000-0002-0084-0216
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
Lee, Seung Hyun(이승현) ORCID logo https://orcid.org/0000-0001-7549-9430
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185378
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