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Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice

Authors
 Eun-Jung Bak  ;  Jinmoon Kim  ;  Sungil Jang  ;  Gye-Hyeong Woo  ;  Ho-Geun Yoon  ;  Yun-Jung Yoo  ;  Jeong-Heon Cha Read More: http://informahealthcare.com/doi/abs/10.3109/00365513.2013.831470 
Citation
 SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, Vol.73(8) : 607-614, 2013 
Journal Title
 SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 
ISSN
 0036-5513 
Issue Date
2013
MeSH
Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Animals ; Blood Glucose/drug effects* ; Body Weight ; Eating/drug effects ; Gallic Acid/adverse effects ; Gallic Acid/metabolism ; Gallic Acid/pharmacology* ; Glucose Intolerance/drug therapy* ; Glucose Tolerance Test ; Insulin/blood ; Insulin/metabolism ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; PPAR gamma/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Triglycerides/blood* ; Triglycerides/metabolism
Keywords
Gallic acid ; diet-induced obesity mice ; glucose tolerance ; adipocyte ; PPARγ
Abstract
Gallic acid, a phenolic phytochemical, has been shown to exert a variety of effects, including anti-oxidative, anti- carcinogenic, anti-allergic, and anti-inflammatory effects. In this study, we attempted to determine whether gallic acid affects metabolic syndrome such as obesity and diabetes. Diet-induced obesity mice were treated intraperitoneally once per day with gallic acid (10 mg/kg/day). After 2 weeks of treatment, the mice were sacrificed to collect the blood for metabolic parameter assessments, and the adipose tissues and liver to weigh and analyze. The triglyceride concentrations were significantly improved in the gallic acid group relative to those measured in the control group. And most importantly, the blood glucose concentrations in the gallic acid group were significantly improved. In the epididymal white adipose tissue of the gallic acid group, adipocyte size was reduced, PPARγ expression was induced, and the Akt signaling pathway was activated. Our results demonstrate that gallic acid improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity. The findings of an upregulation of PPARγ expression and Akt activation also contribute to our current understanding of the mechanisms underlying the effects of gallic acid on glucose metabolism.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365513.2013.831470
DOI
10.3109/00365513.2013.831470
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Moon(김진문)
Bak, Eun-Jung(박은정) ORCID logo https://orcid.org/0000-0002-7976-8594
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88798
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