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Evidence for expansion-based temporal BMP4/NOGGIN interactions in specifying periodontium morphogenesis

Authors
 Jae-Young Kim  ;  Sung-Won Cho  ;  Han-Sung Jung  ;  Chong-Kwan Kim  ;  Seong-Ho Choi  ;  Jinglei Cai  ;  Jong-Min Lee  ;  Min-Jung Lee  ;  Heui-Jung Hwang 
Citation
 CELL AND TISSUE RESEARCH, Vol.330(1) : 123-132, 2007 
Journal Title
 CELL AND TISSUE RESEARCH 
ISSN
 0302-766X 
Issue Date
2007
Abstract
Dental follicle cells in the periodontium are known to have the ability to differentiate into fibroblasts, cementoblasts, and osteoblasts during mouse periodontal development. From embryonic day 14 (E14) to postnatal day 11 (PN11), histological observations showed dramatic alterations in the relative width of the periodontal ligament (PDL)-forming region between the alveolar bone-forming and tooth root-forming area. At PN2, the width of the PDL-forming region showed a minimum, but with a higher expression of NOGGIN and proliferation cell nuclear antigen than the other regions. At PN11, the relative width of the PDL-forming region had expanded. Transplantation of individual regions of the developing tooth germ under the kidney renal capsule showed that dental follicle cells at E14 possessed the potential to develop into mineralized tissue after 3 weeks. These results suggested that the recovery of PDL width at PN11 may have resulted from cell proliferation and molecular interactions between osteogenic factors and their antagonists, such as interactions between bone morphogenetic protein 4 (BMP4) and NOGGIN, simlilar to those observed in suture, limb, and somite formation. To confirm the molecular interaction between BMP4 and NOGGIN, NOGGIN-protein bead implantation onto cultures was employed in vitro. This study thus indicates that harmonious interactions between NOGGIN and BMP in PDL-forming cells, which show higher cell proliferation than neighboring cells, might be important for proper periodontium development.
Full Text
http://link.springer.com/article/10.1007%2Fs00441-007-0434-2
DOI
10.1007/s00441-007-0434-2
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Kim, Chong Kwan(김종관)
Lee, Min Jung(이민정)
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
Hwang, Heui Jung(황희정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95808
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