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Evidence for expansion-based temporal BMP4/NOGGIN interactions in specifying periodontium morphogenesis

DC FieldValueLanguage
dc.contributor.author김재영-
dc.contributor.author김종관-
dc.contributor.author이민정-
dc.contributor.author이종민-
dc.contributor.author정한성-
dc.contributor.author조성원-
dc.contributor.author최성호-
dc.contributor.author황희정-
dc.date.accessioned2014-12-21T16:30:00Z-
dc.date.available2014-12-21T16:30:00Z-
dc.date.issued2007-
dc.identifier.issn0302-766X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95808-
dc.description.abstractDental follicle cells in the periodontium are known to have the ability to differentiate into fibroblasts, cementoblasts, and osteoblasts during mouse periodontal development. From embryonic day 14 (E14) to postnatal day 11 (PN11), histological observations showed dramatic alterations in the relative width of the periodontal ligament (PDL)-forming region between the alveolar bone-forming and tooth root-forming area. At PN2, the width of the PDL-forming region showed a minimum, but with a higher expression of NOGGIN and proliferation cell nuclear antigen than the other regions. At PN11, the relative width of the PDL-forming region had expanded. Transplantation of individual regions of the developing tooth germ under the kidney renal capsule showed that dental follicle cells at E14 possessed the potential to develop into mineralized tissue after 3 weeks. These results suggested that the recovery of PDL width at PN11 may have resulted from cell proliferation and molecular interactions between osteogenic factors and their antagonists, such as interactions between bone morphogenetic protein 4 (BMP4) and NOGGIN, simlilar to those observed in suture, limb, and somite formation. To confirm the molecular interaction between BMP4 and NOGGIN, NOGGIN-protein bead implantation onto cultures was employed in vitro. This study thus indicates that harmonious interactions between NOGGIN and BMP in PDL-forming cells, which show higher cell proliferation than neighboring cells, might be important for proper periodontium development.-
dc.description.statementOfResponsibilityopen-
dc.format.extent123~132-
dc.relation.isPartOfCELL AND TISSUE RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEvidence for expansion-based temporal BMP4/NOGGIN interactions in specifying periodontium morphogenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontology (치주과학)-
dc.contributor.googleauthorJae-Young Kim-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorChong-Kwan Kim-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorJinglei Cai-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorHeui-Jung Hwang-
dc.identifier.doi10.1007/s00441-007-0434-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03758-
dc.contributor.localIdA03837-
dc.contributor.localIdA04498-
dc.contributor.localIdA04081-
dc.contributor.localIdA00862-
dc.contributor.localIdA02785-
dc.contributor.localIdA00914-
dc.contributor.localIdA04640-
dc.relation.journalcodeJ00474-
dc.identifier.eissn1432-0878-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00441-007-0434-2-
dc.contributor.alternativeNameKim, Jae Young-
dc.contributor.alternativeNameKim, Chong Kwan-
dc.contributor.alternativeNameLee, Min Jung-
dc.contributor.alternativeNameLee, Jong Min-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.alternativeNameChoi, Seong Ho-
dc.contributor.alternativeNameHwang, Heui Jung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorHwang, Heui Jung-
dc.contributor.affiliatedAuthorChoi, Seong Ho-
dc.contributor.affiliatedAuthorKim, Jae Young-
dc.contributor.affiliatedAuthorLee, Min Jung-
dc.contributor.affiliatedAuthorKim, Chong Kwan-
dc.contributor.affiliatedAuthorLee, Jong Min-
dc.rights.accessRightsnot free-
dc.citation.volume330-
dc.citation.number1-
dc.citation.startPage123-
dc.citation.endPage132-
dc.identifier.bibliographicCitationCELL AND TISSUE RESEARCH, Vol.330(1) : 123-132, 2007-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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