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Shh signaling is essential for rugae morphogenesis in mice.

Authors
 Jong-Min Lee  ;  Seita Miyazawa  ;  Han-Sung Jung  ;  Sung-Won Cho  ;  Shigeru Kondo  ;  Jae-Ho Lee  ;  Byung-Jai Choi  ;  Dae-Woon Kang  ;  Hyuk-Jae Kwon  ;  Jeong-Oh Shin 
Citation
 Histochemistry and Cell Biology, Vol.136(6) : 663-675, 2011 
Journal Title
 Histochemistry and Cell Biology 
ISSN
 0948-6143 
Issue Date
2011
Abstract
Palatal ridges, or rugae palatinae, are corrugated structures observed in the hard palate region. They are found in most mammalian species, but their number and arrangement are species-specific. Nine palatal rugae are found in the mouse secondary palate. Previous studies have shown that epithelial Shh signaling in the palatal ridge plays an important role during rugae development. Moreover, Wnt family members, including LEF1, play a functional role in orofacial morphogenesis. To explore the function of Shh during rugae development, we utilized the maternal transfer of 5E1 (anti-Shh antibody) to mouse embryos. 5E1 induced abnormal rugae patterning characterized by a spotted shape of palatal ridge rather than a stripe. The expression patterns of Shh and Shh-related genes, Sostdc1, Lef1 and Ptch1, were disrupted following 5E1 injection. Moreover, rugae-specific cell proliferation and inter-rugae-specific apoptosis were affected by inhibition of Shh signaling. We hypothesize that the altered gene expression patterns and the change in molecular events caused by the inhibition of Shh signaling may have induced abnormal rugae patterning. Furthermore, we propose a reaction-diffusion model generated by Wnt, Shh and Sostdc1 signaling. In this study, we show that Sostdc1, a secreted inhibitor of the Wnt pathway, is a downstream target of Shh and hypothesize that the interaction of Wnt, Shh and Sostdc1 is a pivotal mechanism controlling the spatial patterning of palatal rugae.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94586
DOI
10.1007/s00418-011-0870-7
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실)
Yonsei Authors
권혁제(Kwon, Hyuk Jae) ; 신정오(Shin, Jeong Oh) ; 이종민(Lee, Jong Min) ; 정한성(Jung, Han Sung) ; 조성원(Cho, Sung Won) ; 최병재(Choi, Byung Jai)
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Full Text
http://link.springer.com/article/10.1007%2Fs00418-011-0870-7
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