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Comorbidity index for predicting mortality at 6 months after reperfusion therapy

Authors
 Hyo Suk Nam  ;  Young Dae Kim  ;  Joonsang Yoo  ;  Hyungjong Park  ;  Byung Moon Kim  ;  Oh Young Bang  ;  Hyeon Chang Kim  ;  Euna Han  ;  Dong Joon Kim  ;  Joonyung Heo  ;  Minyoung Kim  ;  Jin Kyo Choi  ;  Kyung-Yul Lee  ;  Hye Sun Lee  ;  Dong Hoon Shin  ;  Hye-Yeon Choi  ;  Sung-Il Sohn  ;  Jeong-Ho Hong  ;  Jong Yun Lee  ;  Jang-Hyun Baek  ;  Gyu Sik Kim  ;  Woo-Keun Seo  ;  Jong-Won Chung  ;  Seo Hyun Kim  ;  Tae-Jin Song  ;  Sang Won Han  ;  Joong Hyun Park  ;  Jinkwon Kim  ;  Yo Han Jung  ;  Han-Jin Cho  ;  Seong Hwan Ahn  ;  Sung Ik Lee  ;  Kwon-Duk Seo  ;  Ji Hoe Heo 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 5963, 2021-03 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2021-03
Abstract
The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in patients with acute stroke receiving reperfusion therapy. The 19 comorbidities included in the Charlson comorbidity index were adopted and modified. We developed a statistical model and it was validated using data from a prospective cohort. Among 1026 patients in the retrospective nationwide reperfusion therapy registry, 845 (82.3%) had at least one comorbidity. As the number of comorbidities increased, the likelihood of mortality within 6 months also increased (p < 0.001). Six out of the 19 comorbidities were included for developing the reperfusion comorbidity index on the basis of the odds ratios in the multivariate logistic regression analysis. This index showed good prediction of 6-month mortality in the retrospective cohort (area under the curve [AUC], 0.747; 95% CI, 0.704-0.790) and in 333 patients in the prospective cohort (AUC, 0.784; 95% CI, 0.709-0.859). Consideration of comorbidities might be helpful for the prediction of the 6-month mortality in patients with acute ischemic stroke who receive reperfusion therapy.
Files in This Item:
T202100972.pdf Download
DOI
10.1038/s41598-021-85390-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Byung Moon(김병문) ORCID logo https://orcid.org/0000-0001-8593-6841
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Hyungjong(박형종)
Yoo, Joon Sang(유준상) ORCID logo https://orcid.org/0000-0003-1169-6798
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Jung, Yo Han(정요한)
Heo, Joon Nyung(허준녕)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182303
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