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Improving the Clinical Outcome in Stroke Patients Receiving Thrombolytic or Endovascular Treatment in Korea: From the SECRET Study

 Young Dae Kim  ;  Ji Hoe Heo  ;  Joonsang Yoo  ;  Hyungjong Park  ;  Byung Moon Kim  ;  Oh Young Bang  ;  Hyeon Chang Kim  ;  Euna Han  ;  Dong Joon Kim  ;  JoonNyung Heo  ;  Minyoung Kim  ;  Jin Kyo Choi  ;  Kyung-Yul Lee  ;  Hye Sun Lee  ;  Dong Hoon Shin  ;  Hye-Yeon Choi  ;  Sung-Il Sohn  ;  Jeong-Ho Hong  ;  Jang-Hyun Baek  ;  Gyu Sik Kim  ;  Woo-Keun Seo  ;  Jong-Won Chung  ;  Seo Hyun Kim  ;  Tae-Jin Song  ;  Sang Won Han  ;  Joong Hyun Park  ;  Jinkwon Kim  ;  Yo Han Jung  ;  Han-Jin Cho  ;  Seong Hwan Ahn  ;  Sung Ik Lee  ;  Kwon-Duk Seo  ;  Hyo Suk Nam 
 JOURNAL OF CLINICAL MEDICINE, Vol.9(3) : 717, 2020-03 
Journal Title
Issue Date
ischemic stroke ; outcome ; reperfusion ; therapy
We investigated whether there was an annual change in outcomes in patients who received the thrombolytic therapy or endovascular treatment (EVT) in Korea. This analysis was performed using data from a nationwide multicenter registry for exploring the selection criteria of patients who would benefit from reperfusion therapies in Korea. We compared the annual changes in the modified Rankin scale (mRS) at discharge and after 90 days and the achievement of successful recanalization from 2012 to 2017. We also investigated the determinants of favorable functional outcomes. Among 1230 included patients, the improvement of functional outcome at discharge after reperfusion therapy was noted as the calendar year increased (p < 0.001). The proportion of patients who were discharged to home significantly increased (from 45.6% in 2012 to 58.5% in 2017) (p < 0.001). The successful recanalization rate increased over time from 78.6% in 2012 to 85.1% in 2017 (p = 0.006). Time from door to initiation of reperfusion therapy decreased over the years (p < 0.05). These secular trends of improvements were also observed in 1203 patients with available mRS data at 90 days (p < 0.05). Functional outcome was associated with the calendar year, age, initial stroke severity, diabetes, preadmission disability, intervals from door to reperfusion therapy, and achievement of successful recanalization. This study demonstrated the secular trends of improvement in functional outcome and successful recanalization rate in patients who received reperfusion therapy in Korea.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Byung Moon(김병문) ORCID logo https://orcid.org/0000-0001-8593-6841
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Hyungjong(박형종)
Yoo, Joon Sang(유준상) ORCID logo https://orcid.org/0000-0003-1169-6798
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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