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GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy

Authors
 Hui Won Jang  ;  So Won Kim  ;  Yang-Je Cho  ;  Kyoung Heo  ;  Byung In Lee  ;  Sang Kun Lee  ;  In-Jin Jang  ;  Min Goo Lee  ;  Won-Joo Kim  ;  Ji Hyun Lee 
Citation
 Epilepsy Research, Vol.115 : 88-94, 2015 
Journal Title
 Epilepsy Research 
ISSN
 0920-1211 
Issue Date
2015
MeSH
Anticonvulsants/adverse effects* ; Anticonvulsants/therapeutic use ; Asian Continental Ancestry Group/genetics ; Cohort Studies ; Drug Eruptions/genetics* ; Epilepsy/drug therapy ; Epilepsy/genetics* ; Exanthema/chemically induced ; Exanthema/genetics* ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide* ; Republic of Korea ; Triazines/adverse effects* ; Triazines/therapeutic use
Keywords
Genome wide association study ; Lamotrigine ; Maculopapular eruption
Abstract
PURPOSE: Lamotrigine (LTG)-induced maculopapular eruption (MPE) often causes treatment discontinuation and rising burdens on current healthcare systems. We conducted a genome-wide association study to identify novel susceptibility loci associated with LTG-induced MPE in patients with epilepsy. MATERIALS AND METHODS: We enrolled patients with LTG-induced MPE (n=34) and utilized the Korea Association Resource project cohort as a control group (n=1214). We explored associations between LTG-induced MPE and single nucleotide polymorphisms (SNPs) through imputation and replicated these associations in samples from 59 LTG-induced MPE cases and 98 LTG tolerant-controls. RESULTS: We found two novel SNPs associated with LTG-induced MPE: rs12668095 near CRAMP1L/TMEM204/IFT140/HN1L (P=4.89×10(-7)) and rs79007183 near TNS3 (P=3.15×10(-10)), both of which were replicated in an independent cohort. CONCLUSION: These two validated SNPs may be good candidate markers for predicting LTG-induced MPE in epilepsy patients, although further experimental validation is needed.
Full Text
http://www.sciencedirect.com/science/article/pii/S0920121115300048
DOI
10.1016/j.eplepsyres.2015.05.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Lee, Byung In(이병인)
Lee, Ji Hyun(이지현)
Cho, Yang Je(조양제)
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140431
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