0 376

Cited 3 times in

GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy

DC FieldValueLanguage
dc.contributor.author김원주-
dc.contributor.author이민구-
dc.contributor.author이병인-
dc.contributor.author이지현-
dc.contributor.author조양제-
dc.contributor.author허경-
dc.date.accessioned2016-02-04T11:26:31Z-
dc.date.available2016-02-04T11:26:31Z-
dc.date.issued2015-
dc.identifier.issn0920-1211-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140431-
dc.description.abstractPURPOSE: Lamotrigine (LTG)-induced maculopapular eruption (MPE) often causes treatment discontinuation and rising burdens on current healthcare systems. We conducted a genome-wide association study to identify novel susceptibility loci associated with LTG-induced MPE in patients with epilepsy. MATERIALS AND METHODS: We enrolled patients with LTG-induced MPE (n=34) and utilized the Korea Association Resource project cohort as a control group (n=1214). We explored associations between LTG-induced MPE and single nucleotide polymorphisms (SNPs) through imputation and replicated these associations in samples from 59 LTG-induced MPE cases and 98 LTG tolerant-controls. RESULTS: We found two novel SNPs associated with LTG-induced MPE: rs12668095 near CRAMP1L/TMEM204/IFT140/HN1L (P=4.89×10(-7)) and rs79007183 near TNS3 (P=3.15×10(-10)), both of which were replicated in an independent cohort. CONCLUSION: These two validated SNPs may be good candidate markers for predicting LTG-induced MPE in epilepsy patients, although further experimental validation is needed.-
dc.description.statementOfResponsibilityopen-
dc.format.extent88~94-
dc.relation.isPartOfEPILEPSY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnticonvulsants/adverse effects*-
dc.subject.MESHAnticonvulsants/therapeutic use-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHCohort Studies-
dc.subject.MESHDrug Eruptions/genetics*-
dc.subject.MESHEpilepsy/drug therapy-
dc.subject.MESHEpilepsy/genetics*-
dc.subject.MESHExanthema/chemically induced-
dc.subject.MESHExanthema/genetics*-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHumans-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTriazines/adverse effects*-
dc.subject.MESHTriazines/therapeutic use-
dc.titleGWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorHui Won Jang-
dc.contributor.googleauthorSo Won Kim-
dc.contributor.googleauthorYang-Je Cho-
dc.contributor.googleauthorKyoung Heo-
dc.contributor.googleauthorByung In Lee-
dc.contributor.googleauthorSang Kun Lee-
dc.contributor.googleauthorIn-Jin Jang-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorWon-Joo Kim-
dc.contributor.googleauthorJi Hyun Lee-
dc.identifier.doi10.1016/j.eplepsyres.2015.05.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00771-
dc.contributor.localIdA02781-
dc.contributor.localIdA02797-
dc.contributor.localIdA03851-
dc.contributor.localIdA04341-
dc.contributor.localIdA03214-
dc.relation.journalcodeJ00796-
dc.identifier.eissn1872-6844-
dc.identifier.pmid26220383-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0920121115300048-
dc.subject.keywordGenome wide association study-
dc.subject.keywordLamotrigine-
dc.subject.keywordMaculopapular eruption-
dc.contributor.alternativeNameKim, Won Joo-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.alternativeNameLee, Byung In-
dc.contributor.alternativeNameLee, Ji Hyun-
dc.contributor.alternativeNameCho, Yang Je-
dc.contributor.alternativeNameHeo, Kyoung-
dc.contributor.affiliatedAuthorKim, Won Joo-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.contributor.affiliatedAuthorLee, Byung In-
dc.contributor.affiliatedAuthorCho, Yang Je-
dc.contributor.affiliatedAuthorHeo, Kyoung-
dc.contributor.affiliatedAuthorLee, Ji Hyun-
dc.rights.accessRightsnot free-
dc.citation.volume115-
dc.citation.startPage88-
dc.citation.endPage94-
dc.identifier.bibliographicCitationEPILEPSY RESEARCH, Vol.115 : 88-94, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.