Browsing by Yonsei Author : Kim, Hyongbum

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Kim, Hyongbum [김형범]
Department :
College of Medicine (의과대학) - Dept. of Pharmacology (약리학교실)
Scopus ID :
Scopus (24280276300)

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Issue DateTitleJournal Title
2024Deep learning models to predict the editing efficiencies and outcomes of diverse base editorsNATURE BIOTECHNOLOGY
2023Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9sNATURE METHODS
2023Prediction of efficiencies for diverse prime editing systems in multiple cell typesCELL
2023In vivo application of base and prime editing to treat inherited retinal diseasesPROGRESS IN RETINAL AND EYE RESEARCH
2023DNA double-strand break-free CRISPR interference delays Huntington's disease progression in mice COMMUNICATIONS BIOLOGY
2023Sniper2L is a high-fidelity Cas9 variant with high activityNATURE CHEMICAL BIOLOGY
2022Adherens junctions organize size-selective proteolytic hotspots critical for Notch signallingNATURE CELL BIOLOGY
2022Magnetogenetics with Piezo1 Mechanosensitive Ion Channel for CRISPR Gene EditingNANO LETTERS
2022High-throughput functional evaluation of human cancer-associated mutations using base editorsNATURE BIOTECHNOLOGY
2022Generation of mutation-corrected induced pluripotent stem cell lines derived from adrenoleukodystrophy patient by using homology directed repair STEM CELL RESEARCH
2022Basic Principles and Clinical Applications of CRISPR-Based Genome Editing YONSEI MEDICAL JOURNAL
2022In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model THERANOSTICS
2022Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseasesNATURE BIOMEDICAL ENGINEERING
2021Improving CRISPR tools by elucidating DNA repairNATURE BIOTECHNOLOGY
2021Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain NATURE COMMUNICATIONS
2021Recording of elapsed time and temporal information about biological events using Cas9CELL
2021Predicting the efficiency of prime editing guide RNAs in human cellsNATURE BIOTECHNOLOGY
2020Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancerCELL DEATH AND DIFFERENTIATION
2020Prediction of the sequence-specific cleavage activity of Cas9 variantsNATURE BIOTECHNOLOGY
2020Sequence-specific prediction of the efficiencies of adenine and cytosine base editorsNATURE BIOTECHNOLOGY
2020Chemical Controllable Gene Drive in DrosophilaACS SYNTHETIC BIOLOGY
2020High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cellsNATURE BIOMEDICAL ENGINEERING
2019LIN28A loss of function is associated with Parkinson's disease pathogenesis EMBO JOURNAL
2019SpCas9 activity prediction by DeepSpCas9, a deep learning-based model with high generalization performance Science Advances
2019Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis Molecular Therapy Oncolytics
2019Therapeutic application of the CRISPR system: current issues and new prospectsHuman Genetics
2019En bloc and segmental deletions of human XIST reveal X chromosome inactivation-involving RNA elements NUCLEIC ACIDS RESEARCH
2018In vivo gene correction with targeted sequence substitution through microhomology-mediated end joiningBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2018Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical DyslaminationNEURON
2018Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruptionNUCLEIC ACIDS RESEARCH
2018Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth GENOME RESEARCH
2018Deep learning improves prediction of CRISPR-Cpf1 guide RNA activityNATURE BIOTECHNOLOGY
2017Targeted Genome Engineering to Control VEGF Expression in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells: Potential Implications for the Treatment of Myocardial Infarction STEM CELLS TRANSLATIONAL MEDICINE
2017RanBPM: a potential therapeutic target for modulating diverse physiological disordersDRUG DISCOVERY TODAY
2017Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. NATURE COMMUNICATIONS
2017Concise Review: Fate Determination of Stem Cells by Deubiquitinating EnzymesSTEM CELLS
2017In vivo high-throughput profiling of CRISPR-Cpf1 activityNATURE METHODS
2017Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA for Genome EditingMethods in Molecular Biology (Clifton, N.J.)
2017Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical DysplasiaAMERICAN JOURNAL OF HUMAN GENETICS
2016Heroes of peer review: Hyongbum (Henry) Kim GENOME BIOLOGY
2016Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis PLOS ONE
2016Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transportersJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
2016In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia MOLECULAR THERAPY
2016Generation of ΔF508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editingBIOTECHNOLOGY LETTERS
2016Astroglial Activation by an Enriched Environment after Transplantation of Mesenchymal Stem Cells Enhances Angiogenesis after Hypoxic-Ischemic Brain Injury INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2016Regulation of pluripotency and differentiation by deubiquitinating enzymes.CELL DEATH AND DIFFERENTIATION
2016Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice SCIENTIFIC REPORTS
2016Designed nucleases for targeted genome editing PLANT BIOTECHNOLOGY JOURNAL
2015CRISPR/Cas9 system as an innovative genetic engineering tool: Enhancements in sequence specificity and delivery methodsBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
2015Effective Gene Delivery into Human Stem Cells with a Cell-Targeting Peptide-Modified Bioreducible PolymerSMALL