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Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.

Authors
 Bongki Cho  ;  Hyo Min Cho  ;  Youhwa Jo  ;  Hee Dae Kim  ;  Myoungjae Song  ;  Cheil Moon  ;  Hyongbum Kim  ;  Kyungjin Kim  ;  Hiromi Sesaki  ;  Im Joo Rhyu  ;  Hyun Kim  ;  Woong Sun 
Citation
 Nature Communications, Vol.8(15754) : 1-17, 2017 
Journal Title
 Nature Communications 
Issue Date
2017
Abstract
Mitochondrial division is critical for the maintenance and regulation of mitochondrial function, quality and distribution. This process is controlled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitochondrial outer membrane (OMM). Although mitochondrial physiology, including oxidative phosphorylation, is also important for efficient mitochondrial division, morphological alterations of the mitochondrial inner-membrane (IMM) have not been clearly elucidated. Here we report spontaneous and repetitive constriction of mitochondrial inner compartment (CoMIC) associated with subsequent division in neurons. Although CoMIC is potentiated by inhibition of Drp1 and occurs at the potential division spots contacting the endoplasmic reticulum, it appears on IMM independently of OMM. Intra-mitochondrial influx of Ca2+ induces and potentiates CoMIC, and leads to K+-mediated mitochondrial bulging and depolarization. Synergistically, optic atrophy 1 (Opa1) also regulates CoMIC via controlling Mic60-mediated OMM-IMM tethering. Therefore, we propose that CoMIC is a priming event for efficient mitochondrial division
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161041
DOI
10.1038/ncomms15754
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
Yonsei Authors
김형범(Kim, Hyongbum)
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