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Maleimidyl magnetic nanoplatform for facile molecular MRI

 Dan Heo  ;  Eugene Lee  ;  Minhee Ku  ;  Seungyeon Hwang  ;  Bongjune Kim  ;  Yeonji Park  ;  Young Han Lee  ;  Yong-Min Huh  ;  Seungjoo Haam  ;  Jae-Ho Cheong  ;  Jaemoon Yang  ;  Jin-Suck Suh 
 NANOTECHNOLOGY, Vol.25(27) : 275102, 2014 
Journal Title
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Animals ; Biomarkers/chemistry ; Cell Survival/drug effects ; HEK293 Cells ; Humans ; MCF-7 Cells ; Magnetic Phenomena ; Magnetic Resonance Imaging/instrumentation* ; Magnetite Nanoparticles/chemistry* ; Male ; Maleimides/chemical synthesis* ; Maleimides/chemistry* ; Mice ; Mice, Inbred BALB C ; Nanotechnology/instrumentation* ; Neoplasms/diagnosis*
maleimidyl ; magnetic nanoplatform ; magnetic resonance imaging ; cancer ; molecular imaging
In this study, we developed the maleimidyl magnetic nanoplatform, which enables functional targeting of a biomarker-specific moiety for molecular imaging via MRI. The maleimide group of the maleimidyl magnetic nanoplatform is conjugated with a thiol group without additional crosslinkers and side products. A physicochemical analysis was conducted to verify the effectiveness of the maleimidyl magnetic nanoplatform, and the existence of the maleimidyl group was investigated using the platform. To prepare biomarker-specific MRI probes, a thiolated aptamer and peptide were immobilized onto the maleimidyl group of the maleimidyl magnetic nanoplatform. The fabricated MRI probes were applied to four cancer cell lines: HT1080, MCF7, MKN45, and HEK293T. To investigate the potential of the molecular MRI probe, the target-biomarker specificity was confirmed without serious cytotoxicity, and in vivo MRI analysis using a xenograft mouse model was demonstrated. We believe these results will be useful for fabricating molecular MRI probes for the diagnosis of cancer.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Lee, Eu Gene(이유진)
Heo, Dan(허단)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
Hwang, Seung Yeon(황승연)
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