Cited 10 times in
Maleimidyl magnetic nanoplatform for facile molecular MRI
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구민희 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 이영한 | - |
dc.contributor.author | 이유진 | - |
dc.contributor.author | 허단 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 황승연 | - |
dc.date.accessioned | 2015-01-06T17:03:26Z | - |
dc.date.available | 2015-01-06T17:03:26Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99274 | - |
dc.description.abstract | In this study, we developed the maleimidyl magnetic nanoplatform, which enables functional targeting of a biomarker-specific moiety for molecular imaging via MRI. The maleimide group of the maleimidyl magnetic nanoplatform is conjugated with a thiol group without additional crosslinkers and side products. A physicochemical analysis was conducted to verify the effectiveness of the maleimidyl magnetic nanoplatform, and the existence of the maleimidyl group was investigated using the platform. To prepare biomarker-specific MRI probes, a thiolated aptamer and peptide were immobilized onto the maleimidyl group of the maleimidyl magnetic nanoplatform. The fabricated MRI probes were applied to four cancer cell lines: HT1080, MCF7, MKN45, and HEK293T. To investigate the potential of the molecular MRI probe, the target-biomarker specificity was confirmed without serious cytotoxicity, and in vivo MRI analysis using a xenograft mouse model was demonstrated. We believe these results will be useful for fabricating molecular MRI probes for the diagnosis of cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers/chemistry | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | HEK293 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MCF-7 Cells | - |
dc.subject.MESH | Magnetic Phenomena | - |
dc.subject.MESH | Magnetic Resonance Imaging/instrumentation* | - |
dc.subject.MESH | Magnetite Nanoparticles/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maleimides/chemical synthesis* | - |
dc.subject.MESH | Maleimides/chemistry* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Nanotechnology/instrumentation* | - |
dc.subject.MESH | Neoplasms/diagnosis* | - |
dc.title | Maleimidyl magnetic nanoplatform for facile molecular MRI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Eugene Lee | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Seungyeon Hwang | - |
dc.contributor.googleauthor | Bongjune Kim | - |
dc.contributor.googleauthor | Yeonji Park | - |
dc.contributor.googleauthor | Young Han Lee | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.identifier.doi | 10.1088/0957-4484/25/27/275102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02967 | - |
dc.contributor.localId | A03016 | - |
dc.contributor.localId | A04346 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04469 | - |
dc.relation.journalcode | J02287 | - |
dc.identifier.eissn | 1361-6528 | - |
dc.identifier.pmid | 24960226 | - |
dc.identifier.url | http://iopscience.iop.org/0957-4484/25/27/275102/ | - |
dc.subject.keyword | maleimidyl | - |
dc.subject.keyword | magnetic nanoplatform | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | molecular imaging | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Lee, Young Han | - |
dc.contributor.alternativeName | Lee, Eu Gene | - |
dc.contributor.alternativeName | Heo, Dan | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.alternativeName | Hwang, Seung Yeon | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Ku, Min Hee | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lee, Young Han | - |
dc.contributor.affiliatedAuthor | Lee, Eu Gene | - |
dc.contributor.affiliatedAuthor | Heo, Dan | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Hwang, Seung Yeon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 27 | - |
dc.citation.startPage | 275102 | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, Vol.25(27) : 275102, 2014 | - |
dc.identifier.rimsid | 55977 | - |
dc.type.rims | ART | - |
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