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Study of freshly excised brain tissues using terahertz imaging

Authors
 Seung Jae Oh  ;  Sang-Hoon Kim  ;  Young Bin Ji  ;  Kiyoung Jeong  ;  Yeonji Park  ;  Jaemoon Yang  ;  Dong Woo Park  ;  Sam Kyu Noh  ;  Seok-Gu Kang  ;  Yong-Min Huh  ;  Joo-Hiuk Son  ;  Jin-Suck Suh 
Citation
 Biomedical Optics Express, Vol.5(8) : 2837-2842, 2014 
Journal Title
 Biomedical Optics Express 
ISSN
 2156-7085 
Issue Date
2014
Abstract
We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.
Files in This Item:
T201402330.pdf Download
DOI
10.1364/BOE.5.002837
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
강석구(Kang, Seok Gu) ORCID logo https://orcid.org/0000-0001-5676-2037
김상훈(Kim, Sang Hoon)
박연지(Park, Yeon Ji)
서진석(Suh, Jin Suck)
양재문(Yang, Jae Moon) ORCID logo https://orcid.org/0000-0001-7365-0395
오승재(Oh, Seung Jae)
정기영(Jeong, Ki Young)
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99258
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