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Study of freshly excised brain tissues using terahertz imaging

Authors
 Seung Jae Oh  ;  Sang-Hoon Kim  ;  Young Bin Ji  ;  Kiyoung Jeong  ;  Yeonji Park  ;  Jaemoon Yang  ;  Dong Woo Park  ;  Sam Kyu Noh  ;  Seok-Gu Kang  ;  Yong-Min Huh  ;  Joo-Hiuk Son  ;  Jin-Suck Suh 
Citation
 Biomedical Optics Express, Vol.5(8) : 2837-2842, 2014 
Journal Title
 Biomedical Optics Express 
ISSN
 2156-7085 
Issue Date
2014
Keywords
(170.3880) Medical and biological imaging ; (170.6795) Terahertz imaging
Abstract
We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.
Files in This Item:
T201402330.pdf Download
DOI
10.1364/BOE.5.002837
Appears in Collections:
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Kim, Sang Hoon(김상훈)
Park, Yeon Ji(박연지)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Oh, Seung Jae(오승재)
Jeong, Ki Young(정기영)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99258
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