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Browsing by Yonsei Author : Kang, Seok-Gu

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Name :
Kang, Seok-Gu [강석구]
orcid http://orcid.org/0000-0001-5676-2037
Department :
College of Medicine (의과대학) - Dept. of Neurosurgery (신경외과학교실)
Scopus ID :
Scopus (56566963000)
Medical Student Research Advisor

교수 기본정보

세부 전공
신경외과학/뇌종양
이메일
seokgu9@yuhs.ac

실험실 기본정보

이름
뇌종양이행성연구실
위치
에비슨의생명연구센터(ABMRC) 210호
구분
Wet Lab (80%), Dry Lab (20%)

연구소개

연구 분야
연구 내용
1. 수술 과정을 통해 확보된 다양한 뇌종양 환자 유래 검체를 기반으로, Primary culture를 통해 종양구(tumorsphere) 세포를 획득하고 분리된 세포의 특성을 분석하여, 테스팅 플랫폼 기반으로 새로운 신약을 개발하는 연구를 진행.
2. 교모세포종을 포함한 다양한 뇌종양에서의 발암기원 세포를 규명하고, 해당 발암기원에 기반한 분자적 발암기전을 규명하여 유전자 조절을 통한 치료 표적 검증 연구를 진행.
이미지 :

학생 참여 정보

학생들이 참여하면 좋을 연구
  • - Web lab: Primary cell culture를 통한 종양구세포분리 및 배양, Molecular work (e.g. viability, Western blot, 3D invasion, Neurosphere formation, RNA interference, CRISPR/Cas9 등), 신약 효과 검증 (전임상 단계).
  • - Dry lab: 환자 또는 SVZ 교모세포종 genesis 모델에서 획득한 세포 및 조직을 이용한 전사체 데이터 확보 및 분석(Bulk RNAseq, single cell RNAseq, WES, WGS 등)
학생 참여 시 사용하게 되는 장비 및 프로그램
  • - 장비: Microplate reader (ELISA)/Gel doc go imaging system/ImageQuant 800 (LAS) PCR (APPLIED BIOSYSTEMS)
  • - 프로그램: EndNote/GraphPad Prism/SnapGene(Plasmid map)
참여 전 준비사항
  • 실험동물부 이용자 교육 이수 시, 동물실험 참관 및 참여 가능함.

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Showing results 1 to 50 of 179

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Issue DateTitleJournal Title
2026Extended Reality in Neurosurgery : Surgical Planning, Navigation, Education, and Patient Communication JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
2026Survival analysis of adult midline-located gliomas and diffuse midline gliomas: beyond the H3K27 mutation paradigmJOURNAL OF NEURO-ONCOLOGY
2026Beyond the Tumor Mass: From Initiating Clones to Overt Isocitrate Dehydrogenase-Mutant GliomasDNA AND CELL BIOLOGY
2026Improved tumor control with adjuvant radiotherapy in patients with central neurocytoma: a multicenter studyJOURNAL OF NEURO-ONCOLOGY
2026Portable duplex digital PCR for on-site detection of IDH mutations in gliomasBIOSENSORS & BIOELECTRONICS
2026IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutationSCIENCE
2026Pharmacological transglutaminase 2 inhibition enhances temozolomide response in patient-derived glioblastoma tumorspheresJOURNAL OF NEURO-ONCOLOGY
2026The new Bruton's tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres TRANSLATIONAL ONCOLOGY
2025Deep Learning-Based AI Model for Brain Tumor Segmentation in Digital Pathology and Terahertz ImagingProgress in Biomedical Optics and Imaging - Proceedings of SPIE
2025Restoring the glioblastoma tumor microenvironment by targeting C5a with the antagonist W54011 SCIENTIFIC REPORTS
2025Clinical and molecular characteristics and prognostic factors of diffuse astrocytoma, IDH-wildtype, not elsewhere classifiedJOURNAL OF NEURO-ONCOLOGY
2025Neoadjuvant gamma knife surgery for metastatic brain tumor: clinical use and impact on leptomeningeal seedingJOURNAL OF NEURO-ONCOLOGY
2025Co-blockade of TGFβ and PD-1 Reinvigorates Glioblastoma-Infiltrating CD8+ T Cells That Characteristically Upregulate TGFβRI ExpressionCLINICAL CANCER RESEARCH
2025Focused ultrasound-mediated temozolomide delivery into intact blood-brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma FLUIDS AND BARRIERS OF THE CNS(Fluids and Barriers of the CNS)
2025Comparison of the biological characteristics of glioblastoma tumorspheres obtained from fresh and cryopreserved glioblastoma tissuesJOURNAL OF NEURO-ONCOLOGY
2025Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral HeterogeneityCANCER DISCOVERY
2025Tumor suppressive effect of low-frequency repetitive transcranial magnetic stimulation on glioblastoma progression NEUROTHERAPEUTICS(Neurotherapeutics)
2025Deep Learning-Based AI Model for Brain Tumor Segmentation in Digital Pathology and Terahertz ImagingEuropean Conference on Biomedical Optics, ECBO 2025
2025N-phenylmaleimide induces bioenergetic switch and suppresses tumor growth in glioblastoma tumorspheres by inhibiting SLC25A11 CANCER CELL INTERNATIONAL
2025Differences in Treatment Outcomes Depending on the Adjuvant Treatment Modality in Craniopharyngioma YONSEI MEDICAL JOURNAL
2025Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection MOLECULAR CANCER
2025To Use or Not to Use: Temozolomide in Elderly Patients with IDH Wild-Type MGMT Promoter Unmethylated Glioblastoma Treated with Radiotherapy CANCER RESEARCH AND TREATMENT
2025Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres TRANSLATIONAL ONCOLOGY
2024Deep learning-driven macroscopic AI segmentation model for brain tumor detection via digital pathology: Foundations for terahertz imaging-based AI diagnostics HELIYON
2024Synergistic combination of perphenazine and temozolomide suppresses patient-derived glioblastoma tumorspheresNEURO-ONCOLOGY
2024Nomogram for radiation-induced lymphopenia in patients receiving intensity-modulated radiotherapy based-chemoradiation therapy for newly diagnosed glioblastoma: A multi-institutional study CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
2024Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironmentNEURO-ONCOLOGY
2024Comparison of Glioblastoma Cell Culture Platforms Based on Transcriptional Similarity with Paired Tissue PHARMACEUTICALS
2024Exploring the impedance-matching effect in terahertz reflection imaging of skin tissue BIOMEDICAL OPTICS EXPRESS
2024Rethinking extent of resection of contrast-enhancing and non-enhaning tumor: different survival impacts on adult-type diffuse gliomas in 2021 World Health Organization classificationEUROPEAN RADIOLOGY
202411C-Acetate PET/CT for Reactive Astrogliosis Outperforms 11C-Methionine PET/CT in Glioma Classification and Survival PredictionCLINICAL NUCLEAR MEDICINE
2024High Radiation Dose to the Fornix Causes Symptomatic Radiation Necrosis in Patients with Anaplastic Oligodendroglioma YONSEI MEDICAL JOURNAL
2023Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiformeJOURNAL OF NEURO-ONCOLOGY
2023Dynamic contrast-enhanced MRI radiomics model predicts epidermal growth factor receptor amplification in glioblastoma, IDH-wildtypeJOURNAL OF NEURO-ONCOLOGY
2023Novel Postoperative Serum Biomarkers in Atypical Meningiomas: A Multicenter StudyNEUROSURGERY
2023Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional programBRITISH JOURNAL OF CANCER
2023C5 alpha secreted by tumor mesenchymal stem-like cells mediates resistance to 5-aminolevulinic acid-based photodynamic therapy against glioblastoma tumorspheresJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
2023Leptomeningeal metastases in glioma revisited: incidence and molecular predictors based on postcontrast fluid-attenuated inversion recovery imagingJOURNAL OF NEUROSURGERY
2023The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Survey About Specific Clinical Scenarios (Version 2023.1) Brain Tumor Research and Treatment
2023The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Recommendation Using the Delphi Method (Version 2023.3) Brain Tumor Research and Treatment
2023Revisiting prognostic factors in glioma with leptomeningeal metastases: a comprehensive analysis of clinical and molecular factors and treatment modalities JOURNAL OF NEURO-ONCOLOGY
2023Mesenchymal Stem-Like Cells Derived from the Ventricle More Effectively Enhance Invasiveness of Glioblastoma Than Those Derived from the TumorYONSEI MEDICAL JOURNAL
2022Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheresJOURNAL OF NEURO-ONCOLOGY
2022Adding radiomics to the 2021 WHO updates may improve prognostic prediction for current IDH-wildtype histological lower-grade gliomas with known EGFR amplification and TERT promoter mutation statusEUROPEAN RADIOLOGY
2022Assessing Spatial Distribution of Multicellular Self-Assembly Enables the Prediction of Phenotypic Heterogeneity in Glioblastoma CANCERS
2022Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population SCIENTIFIC REPORTS
2022Tissue Niche Miniature of Glioblastoma Patient Treated with Nano-Awakeners to Induce Suicide of Cancer Stem CellsADVANCED HEALTHCARE MATERIALS
202211 C-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma ClassificationCLINICAL NUCLEAR MEDICINE
2022Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres CANCER CELL INTERNATIONAL
2022Sex as a prognostic factor in adult-type diffuse gliomas: an intergrated clinical and molecular analysis according to the 2021 WHO classificationJOURNAL OF NEURO-ONCOLOGY
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