55 86

Cited 0 times in

Soluble ICAM-1 a Pivotal Communicator between Tumors and Macrophages, Promotes Mesenchymal Shift of Glioblastoma

Authors
 Ki-Chun Yoo  ;  Jae-Hyeok Kang  ;  Mi-Young Choi  ;  Yongjoon Suh  ;  Yi Zhao  ;  Min-Jung Kim  ;  Jong Hee Chang  ;  Jin-Kyoung Shim  ;  Seon-Jin Yoon  ;  Seok-Gu Kang  ;  Su-Jae Lee 
Citation
 ADVANCED SCIENCE, Vol.8(23) : e2102768, 2021-11 
Journal Title
ADVANCED SCIENCE
ISSN
 * 
Issue Date
2021-11
Keywords
glioblastoma (GBM) ; macrophages ; mesenchymal shift ; soluble intercellular adhesion molecule-1 (sICAM-1) ; tumor microenvironment
Abstract
Despite aggressive clinical treatment, recurrence of glioblastoma multiforme (GBM) is unavoidable, and the clinical outcome is still poor. A convincing explanation is the phenotypic transition of GBM cells upon aggressive treatment such as radiotherapy. However, the microenvironmental factors contributing to GBM recurrence after treatment remain unexplored. Here, it is shown that radiation-treated GBM cells produce soluble intercellular adhesion molecule-1 (sICAM-1) which stimulates the infiltration of macrophages, consequently enriching the tumor microenvironment with inflammatory macrophages. Acting as a paracrine factor, tumor-derived sICAM-1 induces macrophages to secrete wingless-type MMTV integration site family, member 3A (WNT3A), which promotes a mesenchymal shift of GBM cells. In addition, blockade of either sICAM-1 or WNT3A diminishes the harmful effect of radiation on tumor progression. Collectively, the findings indicate that cellular crosstalk between GBM and macrophage through sICAM-1-WNT3A oncogenic route is involved in the mesenchymal shift of GBM cells after radiation, and suggest that radiotherapy combined with sICAM-1 targeted inhibition would improve the clinical outcome of GBM patients.
Files in This Item:
T202105404.pdf Download
DOI
10.1002/advs.202102768
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Yoon, Seon Jin(윤선진) ORCID logo https://orcid.org/0000-0002-3255-5081
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187263
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links