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Low-Dose Recombinant Human Bone Morphogenetic Protein-2 to Enhance the Osteogenic Potential of the Schneiderian Membrane in the Early Healing Phase: In Vitro and In Vivo Studies

Authors
 Min-Soo Kim  ;  Joo-Young Kwon  ;  Jung-Seok Lee  ;  Je Seon Song  ;  Seong-Ho Choi  ;  Ui-Won Jung 
Citation
 JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.72(8) : 1480-1494, 2014 
Journal Title
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
ISSN
 0278-2391 
Issue Date
2014
MeSH
Animals ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/pharmacology* ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; In Vitro Techniques ; Male ; Nasal Mucosa/drug effects* ; Osteogenesis/drug effects* ; Rabbits ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacology ; Wound Healing/drug effects* ; X-Ray Microtomography
Abstract
PURPOSE: The objectives of this study were to confirm the osteogenic potential of the Schneiderian membrane and to elucidate the early healing pattern of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2)-coated biphasic calcium phosphate (BCP). MATERIALS AND METHODS:The osteogenic potential of the Schneiderian membrane and enhancement by rhBMP-2 were evaluated by in vitro analysis. RhBMP-2-coated BCP (experimental group) and BCP soaked with saline (control group) were applied to the maxillary sinus in rabbits. After 2 weeks, micro-computed tomographic and histometric analyses were performed. RESULTS:Enhanced osteogenic potential was found when cells from the Schneiderian membrane were treated with rhBMP-2. Micro-computed tomographic analysis showed that the total augmented volume was significantly larger in the experimental group. Different healing patterns were observed in 3 regions, although the area of new bone did not differ significantly. Although more newly formed bone appeared, particularly along the Schneiderian membrane in the experimental group, the difference was not statistically significant. CONCLUSIONS:RhBMP-2 enhanced the osteogenic potential of the Schneiderian membrane in vitro. However, low-dose rhBMP-2-coated BCP failed to exert a statistically significant effect in vivo, although it appeared to be effective in sinus augmentation specifically for the volumetric increase in the early phase.
Full Text
http://www.sciencedirect.com/science/article/pii/S0278239114003401
DOI
10.1016/j.joms.2014.03.027
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Soo(김민수)
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99234
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