Cited 16 times in
Low-Dose Recombinant Human Bone Morphogenetic Protein-2 to Enhance the Osteogenic Potential of the Schneiderian Membrane in the Early Healing Phase: In Vitro and In Vivo Studies
DC Field | Value | Language |
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dc.contributor.author | 김민수 | - |
dc.contributor.author | 송제선 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2015-01-06T17:01:58Z | - |
dc.date.available | 2015-01-06T17:01:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0278-2391 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99234 | - |
dc.description.abstract | PURPOSE: The objectives of this study were to confirm the osteogenic potential of the Schneiderian membrane and to elucidate the early healing pattern of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2)-coated biphasic calcium phosphate (BCP). MATERIALS AND METHODS:The osteogenic potential of the Schneiderian membrane and enhancement by rhBMP-2 were evaluated by in vitro analysis. RhBMP-2-coated BCP (experimental group) and BCP soaked with saline (control group) were applied to the maxillary sinus in rabbits. After 2 weeks, micro-computed tomographic and histometric analyses were performed. RESULTS:Enhanced osteogenic potential was found when cells from the Schneiderian membrane were treated with rhBMP-2. Micro-computed tomographic analysis showed that the total augmented volume was significantly larger in the experimental group. Different healing patterns were observed in 3 regions, although the area of new bone did not differ significantly. Although more newly formed bone appeared, particularly along the Schneiderian membrane in the experimental group, the difference was not statistically significant. CONCLUSIONS:RhBMP-2 enhanced the osteogenic potential of the Schneiderian membrane in vitro. However, low-dose rhBMP-2-coated BCP failed to exert a statistically significant effect in vivo, although it appeared to be effective in sinus augmentation specifically for the volumetric increase in the early phase. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1480~1494 | - |
dc.relation.isPartOf | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/administration & dosage | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacology* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nasal Mucosa/drug effects* | - |
dc.subject.MESH | Osteogenesis/drug effects* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Recombinant Proteins/administration & dosage | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Wound Healing/drug effects* | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.title | Low-Dose Recombinant Human Bone Morphogenetic Protein-2 to Enhance the Osteogenic Potential of the Schneiderian Membrane in the Early Healing Phase: In Vitro and In Vivo Studies | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Min-Soo Kim | - |
dc.contributor.googleauthor | Joo-Young Kwon | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Je Seon Song | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.identifier.doi | 10.1016/j.joms.2014.03.027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02058 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A00462 | - |
dc.contributor.localId | A03185 | - |
dc.relation.journalcode | J01659 | - |
dc.identifier.eissn | 1531-5053 | - |
dc.identifier.pmid | 24931105 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0278239114003401 | - |
dc.contributor.alternativeName | Kim, Min Soo | - |
dc.contributor.alternativeName | Song, Je Seon | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Song, Je Seon | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1480 | - |
dc.citation.endPage | 1494 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.72(8) : 1480-1494, 2014 | - |
dc.identifier.rimsid | 55953 | - |
dc.type.rims | ART | - |
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