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Bone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect

 Eun Joo Choi  ;  Sang Hoon Kang  ;  Hyun Jin Kwon  ;  Sung Won Cho  ;  Hyung Jun Kim 
 Maxillofacial Plastic and Reconstructive Surgery, Vol.36(3) : 94-102, 2014 
Journal Title
 Maxillofacial Plastic and Reconstructive Surgery 
Issue Date
Autogenous autoclaved bone ; BMP carrier ; Bone morphogenetic protein 2 ; Critical bone defect ; Rabbit radius
Purpose: This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery systems using absorbable collagen sponge (ACS) and fibrin glue (FG) were also evaluated. Methods: Radius defects were made in 12 New Zealand white rabbits. After autoclaving, the resected bone was reinserted and fixed. The animals were classified into three groups: only AAB reinserted (group 1, control), and AAB and ErhBMP-2 inserted using an ACS (group 2) or FG (group 3) as a carrier. Animals were sacrificed six or 12 weeks after surgery. Specimens were evaluated using radiology and histology. Results: Micro-computed tomography images showed the best bony union in group 2 at six and 12 weeks after operation. Quantitative analysis showed all indices except trabecular thickness were the highest in group 2 and the lowest in group 1 at twelve weeks. Histologic results showed the greatest bony union between AAB and radial bone at twelve weeks, indicating the highest degree of engraftment. Conclusion: ErhBMP-2 increases bony healing when applied on AAB graft sites. In addition, the ACS was reconfirmed as a useful delivery system for ErhBMP-2.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Hoon(강상훈)
Kwon, Hyun-Jin(권현진) ORCID logo https://orcid.org/0000-0001-7752-6172
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
Choi, Eyn Joo(최은주)
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