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Bone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect

 Eun Joo Choi  ;  Sang Hoon Kang  ;  Hyun Jin Kwon  ;  Sung Won Cho  ;  Hyung Jun Kim 
 Maxillofacial Plastic and Reconstructive Surgery, Vol.36(3) : 94-102, 2014 
Journal Title
Maxillofacial Plastic and Reconstructive Surgery
Issue Date
Autogenous autoclaved bone ; BMP carrier ; Bone morphogenetic protein 2 ; Critical bone defect ; Rabbit radius
This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery systems using absorbable collagen sponge (ACS) and fibrin glue (FG) were also evaluated.
Radius defects were made in 12 New Zealand white rabbits. After autoclaving, the resected bone was reinserted and fixed. The animals were classified into three groups: only AAB reinserted (group 1, control), and AAB and ErhBMP-2 inserted using an ACS (group 2) or FG (group 3) as a carrier. Animals were sacrificed six or 12 weeks after surgery. Specimens were evaluated using radiology and histology.
Micro-computed tomography images showed the best bony union in group 2 at six and 12 weeks after operation. Quantitative analysis showed all indices except trabecular thickness were the highest in group 2 and the lowest in group 1 at twelve weeks. Histologic results showed the greatest bony union between AAB and radial bone at twelve weeks, indicating the highest degree of engraftment.
ErhBMP-2 increases bony healing when applied on AAB graft sites. In addition, the ACS was reconfirmed as a useful delivery system for ErhBMP-2.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Hoon(강상훈)
Kwon, Hyun-Jin(권현진) ORCID logo https://orcid.org/0000-0001-7752-6172
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
Choi, Eyn Joo(최은주)
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