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Bone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect

DC Field Value Language
dc.contributor.author강상훈-
dc.contributor.author권현진-
dc.contributor.author김형준-
dc.contributor.author조성원-
dc.contributor.author최은주-
dc.contributor.author김형준-
dc.contributor.author권현진-
dc.date.accessioned2015-01-06T16:56:24Z-
dc.date.available2015-01-06T16:56:24Z-
dc.date.issued2014-
dc.identifier.issn2288-8101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99063-
dc.description.abstractPurpose: This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery systems using absorbable collagen sponge (ACS) and fibrin glue (FG) were also evaluated. Methods: Radius defects were made in 12 New Zealand white rabbits. After autoclaving, the resected bone was reinserted and fixed. The animals were classified into three groups: only AAB reinserted (group 1, control), and AAB and ErhBMP-2 inserted using an ACS (group 2) or FG (group 3) as a carrier. Animals were sacrificed six or 12 weeks after surgery. Specimens were evaluated using radiology and histology. Results: Micro-computed tomography images showed the best bony union in group 2 at six and 12 weeks after operation. Quantitative analysis showed all indices except trabecular thickness were the highest in group 2 and the lowest in group 1 at twelve weeks. Histologic results showed the greatest bony union between AAB and radial bone at twelve weeks, indicating the highest degree of engraftment. Conclusion: ErhBMP-2 increases bony healing when applied on AAB graft sites. In addition, the ACS was reconfirmed as a useful delivery system for ErhBMP-2.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfMaxillofacial Plastic and Reconstructive Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorEun Joo Choi-
dc.contributor.googleauthorSang Hoon Kang-
dc.contributor.googleauthorHyun Jin Kwon-
dc.contributor.googleauthorSung Won Cho-
dc.contributor.googleauthorHyung Jun Kim-
dc.identifier.doi10.14402/jkamprs.2014.36.3.94-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00034-
dc.contributor.localIdA03837-
dc.contributor.localIdA04158-
dc.relation.journalcodeJ02191-
dc.identifier.pmid27489818-
dc.subject.keywordAutogenous autoclaved bone-
dc.subject.keywordBMP carrier-
dc.subject.keywordBone morphogenetic protein 2-
dc.subject.keywordCritical bone defect-
dc.subject.keywordRabbit radius-
dc.contributor.alternativeNameKang, Sang Hoon-
dc.contributor.alternativeNameKwon, Hyun Jin-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.alternativeNameChoi, Eyn Joo-
dc.contributor.affiliatedAuthorKang, Sang Hoon-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorChoi, Eyn Joo-
dc.citation.volume36-
dc.citation.number3-
dc.citation.startPage94-
dc.citation.endPage102-
dc.identifier.bibliographicCitationMaxillofacial Plastic and Reconstructive Surgery, Vol.36(3) : 94-102, 2014-
dc.identifier.rimsid50239-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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