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Bone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect
DC Field | Value | Language |
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dc.contributor.author | 강상훈 | - |
dc.contributor.author | 권현진 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 조성원 | - |
dc.contributor.author | 최은주 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 권현진 | - |
dc.date.accessioned | 2015-01-06T16:56:24Z | - |
dc.date.available | 2015-01-06T16:56:24Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2288-8101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99063 | - |
dc.description.abstract | Purpose: This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery systems using absorbable collagen sponge (ACS) and fibrin glue (FG) were also evaluated. Methods: Radius defects were made in 12 New Zealand white rabbits. After autoclaving, the resected bone was reinserted and fixed. The animals were classified into three groups: only AAB reinserted (group 1, control), and AAB and ErhBMP-2 inserted using an ACS (group 2) or FG (group 3) as a carrier. Animals were sacrificed six or 12 weeks after surgery. Specimens were evaluated using radiology and histology. Results: Micro-computed tomography images showed the best bony union in group 2 at six and 12 weeks after operation. Quantitative analysis showed all indices except trabecular thickness were the highest in group 2 and the lowest in group 1 at twelve weeks. Histologic results showed the greatest bony union between AAB and radial bone at twelve weeks, indicating the highest degree of engraftment. Conclusion: ErhBMP-2 increases bony healing when applied on AAB graft sites. In addition, the ACS was reconfirmed as a useful delivery system for ErhBMP-2. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Maxillofacial Plastic and Reconstructive Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bone Healing properties of Autoclaved Autogenous Bone Grafts lncorporating Recombinant Human Bone Morphogenetic protein-2 and comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Eun Joo Choi | - |
dc.contributor.googleauthor | Sang Hoon Kang | - |
dc.contributor.googleauthor | Hyun Jin Kwon | - |
dc.contributor.googleauthor | Sung Won Cho | - |
dc.contributor.googleauthor | Hyung Jun Kim | - |
dc.identifier.doi | 10.14402/jkamprs.2014.36.3.94 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00034 | - |
dc.contributor.localId | A03837 | - |
dc.contributor.localId | A04158 | - |
dc.relation.journalcode | J02191 | - |
dc.identifier.pmid | 27489818 | - |
dc.subject.keyword | Autogenous autoclaved bone | - |
dc.subject.keyword | BMP carrier | - |
dc.subject.keyword | Bone morphogenetic protein 2 | - |
dc.subject.keyword | Critical bone defect | - |
dc.subject.keyword | Rabbit radius | - |
dc.contributor.alternativeName | Kang, Sang Hoon | - |
dc.contributor.alternativeName | Kwon, Hyun Jin | - |
dc.contributor.alternativeName | Kim, Hyung Jun | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.alternativeName | Choi, Eyn Joo | - |
dc.contributor.affiliatedAuthor | Kang, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Choi, Eyn Joo | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 94 | - |
dc.citation.endPage | 102 | - |
dc.identifier.bibliographicCitation | Maxillofacial Plastic and Reconstructive Surgery, Vol.36(3) : 94-102, 2014 | - |
dc.identifier.rimsid | 50239 | - |
dc.type.rims | ART | - |
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