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One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Authors
 Aastha Kukreja  ;  Eun-Kyung Lim  ;  Byunghoon Kang  ;  Yuna Choi  ;  Taeksu Lee  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol.9(1) : 2489-2498, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF NANOMEDICINE 
ISSN
 1176-9114 
Issue Date
2014
MeSH
Animals ; Carotid Artery Diseases/pathology* ; Contrast Media/chemical synthesis* ; Dextrans/chemistry ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles/chemistry* ; Nanocapsules/administration & dosage ; Nanocapsules/chemistry* ; Nanocapsules/ultrastructure ; Nanocomposites/chemistry ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity
Keywords
atherosclerosis ; dextran ; macrophages ; magnetic nanocrystal ; magnetic resonance imaging
Abstract
In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.
Files in This Item:
T201401512.pdf Download
DOI
10.2147/IJN.S55525
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lim, Eun Kyung(임은경)
Choi, Yu Na(최유나)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98812
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