Cited 5 times in
One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 임은경 | - |
dc.contributor.author | 최유나 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-01-06T16:48:36Z | - |
dc.date.available | 2015-01-06T16:48:36Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98812 | - |
dc.description.abstract | In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2489~2498 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carotid Artery Diseases/pathology* | - |
dc.subject.MESH | Contrast Media/chemical synthesis* | - |
dc.subject.MESH | Dextrans/chemistry | - |
dc.subject.MESH | Image Enhancement/methods | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Magnetite Nanoparticles/chemistry* | - |
dc.subject.MESH | Nanocapsules/administration & dosage | - |
dc.subject.MESH | Nanocapsules/chemistry* | - |
dc.subject.MESH | Nanocapsules/ultrastructure | - |
dc.subject.MESH | Nanocomposites/chemistry | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.title | One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Aastha Kukreja | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Taeksu Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.2147/IJN.S55525 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03391 | - |
dc.contributor.localId | A04130 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01134 | - |
dc.identifier.eissn | 1178-2013 | - |
dc.identifier.pmid | 24904209 | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | dextran | - |
dc.subject.keyword | macrophages | - |
dc.subject.keyword | magnetic nanocrystal | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Lim, Eun Kyung | - |
dc.contributor.alternativeName | Choi, Yu Na | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Yu Na | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2489 | - |
dc.citation.endPage | 2498 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol.9(1) : 2489-2498, 2014 | - |
dc.identifier.rimsid | 39258 | - |
dc.type.rims | ART | - |
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