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Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Authors
 Eun-Kyung Lim  ;  Byunghoon Kang  ;  Yuna Choi  ;  Eunji Jang  ;  Seungmin Han  ;  Kwangyeol Lee  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 Nanotechnology, Vol.25(24) : 245103, 2014 
Journal Title
 Nanotechnology 
ISSN
 0957-4484 
Issue Date
2014
Abstract
We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.
Full Text
http://iopscience.iop.org/0957-4484/25/24/245103/
DOI
10.1088/0957-4484/25/24/245103
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lim, Eun Kyung(임은경)
Choi, Yu Na(최유나)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98780
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