Cited 14 times in
Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 임은경 | - |
dc.contributor.author | 최유나 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-01-06T16:47:38Z | - |
dc.date.available | 2015-01-06T16:47:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98780 | - |
dc.description.abstract | We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | BALB 3T3 Cells | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Coated Materials, Biocompatible | - |
dc.subject.MESH | Contrast Media/chemical synthesis* | - |
dc.subject.MESH | Gadolinium*/chemistry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/instrumentation* | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods | - |
dc.subject.MESH | Metal Nanoparticles*/chemistry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neoplasms/diagnosis* | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Pyrenes/chemistry | - |
dc.title | Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Seungmin Han | - |
dc.contributor.googleauthor | Kwangyeol Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.identifier.doi | 10.1088/0957-4484/25/24/245103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03391 | - |
dc.contributor.localId | A04130 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02287 | - |
dc.identifier.eissn | 1361-6528 | - |
dc.identifier.pmid | 24872113 | - |
dc.identifier.url | http://iopscience.iop.org/0957-4484/25/24/245103/ | - |
dc.subject.keyword | magnetic resonance image | - |
dc.subject.keyword | imaging agent | - |
dc.subject.keyword | gadolinium | - |
dc.subject.keyword | high sensitivity | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Lim, Eun Kyung | - |
dc.contributor.alternativeName | Choi, Yu Na | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Yu Na | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 245103 | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, Vol.25(24) : 245103, 2014 | - |
dc.identifier.rimsid | 39243 | - |
dc.type.rims | ART | - |
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