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Localized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells

Authors
 Yoochan Hong  ;  Minhee Ku  ;  Eugene Lee  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Dae Sung Yoon  ;  Jaemoon Yang 
Citation
 Journal of Biomedical Optics, Vol.19(5) : 51202-51202, 2014 
Journal Title
 Journal of Biomedical Optics 
ISSN
 1083-3668 
Issue Date
2014
Abstract
In this study, we describe the development of a cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance that enables recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of the sensing chip was confirmed using various solvents that have different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto the surface of GNRs, and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed a biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from invasive cancer cells.
Full Text
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1787519
DOI
10.1117/1.JBO.19.5.051202
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
구민희(Ku, Min Hee) ORCID logo https://orcid.org/0000-0002-1674-1474
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
양재문(Yang, Jae Moon) ORCID logo https://orcid.org/0000-0001-7365-0395
이유진(Lee, Eu Gene)
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98035
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