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Cited 16 times in

Localized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells

DC FieldValueLanguage
dc.contributor.author구민희-
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author이유진-
dc.contributor.author허용민-
dc.date.accessioned2015-01-06T16:24:05Z-
dc.date.available2015-01-06T16:24:05Z-
dc.date.issued2014-
dc.identifier.issn1083-3668-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98035-
dc.description.abstractIn this study, we describe the development of a cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance that enables recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of the sensing chip was confirmed using various solvents that have different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto the surface of GNRs, and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed a biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from invasive cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL OPTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBiosensing Techniques/methods*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHGold/chemistry-
dc.subject.MESHHumans-
dc.subject.MESHImmobilized Proteins/chemistry-
dc.subject.MESHImmobilized Proteins/metabolism-
dc.subject.MESHMatrix Metalloproteinase 14/chemistry-
dc.subject.MESHMatrix Metalloproteinase 14/metabolism-
dc.subject.MESHNanotubes/chemistry-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHProteolysis-
dc.subject.MESHSurface Plasmon Resonance/methods*-
dc.titleLocalized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorYoochan Hong-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorEugene Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorDae Sung Yoon-
dc.contributor.googleauthorJaemoon Yang-
dc.identifier.doi10.1117/1.JBO.19.5.051202-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02315-
dc.contributor.localIdA00191-
dc.contributor.localIdA01916-
dc.contributor.localIdA03016-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ01269-
dc.identifier.eissn1560-2281-
dc.identifier.pmid24297057-
dc.identifier.urlhttp://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1787519-
dc.subject.keywordCancer-
dc.subject.keywordDielectrics-
dc.subject.keywordNanoparticles-
dc.subject.keywordSurface plasmons-
dc.subject.keywordSensors-
dc.subject.keywordSignal detection-
dc.subject.keywordGlasses-
dc.subject.keywordRefractive index-
dc.subject.keywordGold-
dc.subject.keywordMetals-
dc.contributor.alternativeNameKu, Min Hee-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameLee, Eu Gene-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorKu, Min Hee-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorLee, Eu Gene-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number5-
dc.citation.startPage51202-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL OPTICS, Vol.19(5) : 51202, 2014-
dc.identifier.rimsid54344-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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