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Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging

Authors
 Eun-Kyung Lim  ;  Bongjune Kim  ;  Yuna Choi  ;  Youngjun Ro  ;  Eun-Jin Cho  ;  Jung Hwan Lee  ;  Sung-Ho Ryu  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.102(1) : 49-59, 2014 
Journal Title
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN
 1549-3296 
Issue Date
2014
MeSH
Animals ; Aptamers, Peptide*/chemistry ; Aptamers, Peptide*/pharmacology ; Contrast Media*/chemistry ; Contrast Media*/pharmacology ; Drug Delivery Systems/methods* ; Humans ; Integrin alphaVbeta3/chemistry* ; Magnetic Fields* ; Magnetic Resonance Angiography* ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles/chemistry* ; Neoplasms, Experimental*/blood supply ; Neoplasms, Experimental*/diagnostic imaging ; Neoplasms, Experimental*/metabolism ; Neovascularization, Pathologic/diagnostic imaging* ; Radiography
Keywords
angiogenesis ; aptamer ; integrin avb3 ; magnetic nanoparticle ; magnetic resonance imaging
Abstract
An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamerαvβ3-conjugated magnetic nanoparticles (Aptαvβ3-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Aptαvβ3-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Aptαvβ3-MNPs have the potential to be used for accurate tumor diagnosis and therapy
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34678/abstract
DOI
10.1002/jbm.a.34678
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lim, Eun Kyung(임은경)
Cho, Eun Jin(조은진)
Choi, Yu Na(최유나)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97949
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