Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging

Abstract

An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamerαvβ3-conjugated magnetic nanoparticles (Aptαvβ3-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Aptαvβ3-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Aptαvβ3-MNPs have the potential to be used for accurate tumor diagnosis and therapy