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Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging

Authors
 Eun-Kyung Lim  ;  Bongjune Kim  ;  Yuna Choi  ;  Youngjun Ro  ;  Eun-Jin Cho  ;  Jung Hwan Lee  ;  Sung-Ho Ryu  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 Journal of Biomedical Materials Research Part A, Vol.102(1) : 49-59, 2014 
Journal Title
 Journal of Biomedical Materials Research Part A 
ISSN
 1549-3296 
Issue Date
2014
Abstract
An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamerαvβ3-conjugated magnetic nanoparticles (Aptαvβ3-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Aptαvβ3-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Aptαvβ3-MNPs have the potential to be used for accurate tumor diagnosis and therapy
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34678/abstract
DOI
10.1002/jbm.a.34678
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
임은경(Lim, Eun Kyung)
조은진(Cho, Eun Jin)
최유나(Choi, Yu Na)
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97949
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