Cited 31 times in
Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 임은경 | - |
dc.contributor.author | 조은진 | - |
dc.contributor.author | 최유나 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-01-06T16:21:12Z | - |
dc.date.available | 2015-01-06T16:21:12Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97949 | - |
dc.description.abstract | An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamerαvβ3-conjugated magnetic nanoparticles (Aptαvβ3-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Aptαvβ3-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Aptαvβ3-MNPs have the potential to be used for accurate tumor diagnosis and therapy | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 49~59 | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aptamers, Peptide*/chemistry | - |
dc.subject.MESH | Aptamers, Peptide*/pharmacology | - |
dc.subject.MESH | Contrast Media*/chemistry | - |
dc.subject.MESH | Contrast Media*/pharmacology | - |
dc.subject.MESH | Drug Delivery Systems/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Integrin alphaVbeta3/chemistry* | - |
dc.subject.MESH | Magnetic Fields* | - |
dc.subject.MESH | Magnetic Resonance Angiography* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Neoplasms, Experimental*/blood supply | - |
dc.subject.MESH | Neoplasms, Experimental*/diagnostic imaging | - |
dc.subject.MESH | Neoplasms, Experimental*/metabolism | - |
dc.subject.MESH | Neovascularization, Pathologic/diagnostic imaging* | - |
dc.subject.MESH | Radiography | - |
dc.title | Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Bongjune Kim | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Youngjun Ro | - |
dc.contributor.googleauthor | Eun-Jin Cho | - |
dc.contributor.googleauthor | Jung Hwan Lee | - |
dc.contributor.googleauthor | Sung-Ho Ryu | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.identifier.doi | 10.1002/jbm.a.34678 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A03391 | - |
dc.contributor.localId | A03885 | - |
dc.contributor.localId | A04130 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01266 | - |
dc.identifier.eissn | 1552-4965 | - |
dc.identifier.pmid | 23568770 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34678/abstract | - |
dc.subject.keyword | angiogenesis | - |
dc.subject.keyword | aptamer | - |
dc.subject.keyword | integrin avb3 | - |
dc.subject.keyword | magnetic nanoparticle | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Lim, Eun Kyung | - |
dc.contributor.alternativeName | Cho, Eun Jin | - |
dc.contributor.alternativeName | Choi, Yu Na | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Lim, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Cho, Eun Jin | - |
dc.contributor.affiliatedAuthor | Choi, Yu Na | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 102 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.102(1) : 49-59, 2014 | - |
dc.identifier.rimsid | 53445 | - |
dc.type.rims | ART | - |
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