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Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

Authors
 Jong Doo Lee  ;  Hae-Jeong Park  ;  Chang Il Park  ;  Myung Chul Lee  ;  Dong Soo Lee  ;  Jae Min Jeong  ;  Jinu Lee  ;  Young Hoon Ryu  ;  Mijin Yun  ;  Jae-Jin Kim  ;  Dong Ik Kim  ;  Eung Yeop Kim  ;  Dong-Wook Rha  ;  Dong Goo Kim  ;  Eun Sook Park 
Citation
 NEUROIMAGE, Vol.34(1) : 19-25, 2007 
Journal Title
 NEUROIMAGE 
ISSN
 1053-8119 
Issue Date
2007
Abstract
Periventricular leukomalacia (PVL) due to hypoxic–ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.
Full Text
http://www.sciencedirect.com/science/article/pii/S1053811906009311
DOI
10.1016/j.neuroimage.2006.09.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Dong Ik(김동익)
Kim, Eung Yeop(김응엽)
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Rha, Dong Wook(나동욱) ORCID logo https://orcid.org/0000-0002-7153-4937
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
Park, Chang Il(박창일)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97178
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