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Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

DC Field Value Language
dc.contributor.author윤미진-
dc.contributor.author이종두-
dc.contributor.author김동구-
dc.contributor.author김동익-
dc.contributor.author김응엽-
dc.contributor.author김재진-
dc.contributor.author나동욱-
dc.contributor.author박은숙-
dc.contributor.author박창일-
dc.contributor.author박해정-
dc.contributor.author유영훈-
dc.date.accessioned2014-12-21T17:13:23Z-
dc.date.available2014-12-21T17:13:23Z-
dc.date.issued2007-
dc.identifier.issn1053-8119-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97178-
dc.description.abstractPeriventricular leukomalacia (PVL) due to hypoxic–ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.-
dc.description.statementOfResponsibilityopen-
dc.format.extent19~25-
dc.relation.isPartOfNEUROIMAGE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorChang Il Park-
dc.contributor.googleauthorMyung Chul Lee-
dc.contributor.googleauthorDong Soo Lee-
dc.contributor.googleauthorJae Min Jeong-
dc.contributor.googleauthorJinu Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorJae-Jin Kim-
dc.contributor.googleauthorDong Ik Kim-
dc.contributor.googleauthorEung Yeop Kim-
dc.contributor.googleauthorDong-Wook Rha-
dc.contributor.googleauthorDong Goo Kim-
dc.contributor.googleauthorEun Sook Park-
dc.identifier.doi10.1016/j.neuroimage.2006.09.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02550-
dc.contributor.localIdA03138-
dc.contributor.localIdA00396-
dc.contributor.localIdA00408-
dc.contributor.localIdA00832-
dc.contributor.localIdA00870-
dc.contributor.localIdA01230-
dc.contributor.localIdA01611-
dc.contributor.localIdA01717-
dc.contributor.localIdA01730-
dc.contributor.localIdA02485-
dc.relation.journalcodeJ02332-
dc.identifier.eissn1095-9572-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1053811906009311-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameKim, Dong Goo-
dc.contributor.alternativeNameKim, Dong Ik-
dc.contributor.alternativeNameKim, Eung Yeop-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNameRha, Dong Wook-
dc.contributor.alternativeNamePark, Eun Sook-
dc.contributor.alternativeNamePark, Chang Il-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorKim, Dong Goo-
dc.contributor.affiliatedAuthorKim, Dong Ik-
dc.contributor.affiliatedAuthorKim, Eung Yeop-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorRha, Dong Wook-
dc.contributor.affiliatedAuthorPark, Eun Sook-
dc.contributor.affiliatedAuthorPark, Chang Il-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume34-
dc.citation.number1-
dc.citation.startPage19-
dc.citation.endPage25-
dc.identifier.bibliographicCitationNEUROIMAGE, Vol.34(1) : 19-25, 2007-
dc.identifier.rimsid55225-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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