Cited 22 times in
Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy
DC Field | Value | Language |
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dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 김동구 | - |
dc.contributor.author | 김동익 | - |
dc.contributor.author | 김응엽 | - |
dc.contributor.author | 김재진 | - |
dc.contributor.author | 나동욱 | - |
dc.contributor.author | 박은숙 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 박해정 | - |
dc.contributor.author | 유영훈 | - |
dc.date.accessioned | 2014-12-21T17:13:23Z | - |
dc.date.available | 2014-12-21T17:13:23Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97178 | - |
dc.description.abstract | Periventricular leukomalacia (PVL) due to hypoxic–ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 19~25 | - |
dc.relation.isPartOf | NEUROIMAGE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Hae-Jeong Park | - |
dc.contributor.googleauthor | Chang Il Park | - |
dc.contributor.googleauthor | Myung Chul Lee | - |
dc.contributor.googleauthor | Dong Soo Lee | - |
dc.contributor.googleauthor | Jae Min Jeong | - |
dc.contributor.googleauthor | Jinu Lee | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Jae-Jin Kim | - |
dc.contributor.googleauthor | Dong Ik Kim | - |
dc.contributor.googleauthor | Eung Yeop Kim | - |
dc.contributor.googleauthor | Dong-Wook Rha | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Eun Sook Park | - |
dc.identifier.doi | 10.1016/j.neuroimage.2006.09.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A00832 | - |
dc.contributor.localId | A00870 | - |
dc.contributor.localId | A01230 | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A01730 | - |
dc.contributor.localId | A02485 | - |
dc.relation.journalcode | J02332 | - |
dc.identifier.eissn | 1095-9572 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1053811906009311 | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Eung Yeop | - |
dc.contributor.alternativeName | Kim, Jae Jin | - |
dc.contributor.alternativeName | Rha, Dong Wook | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.contributor.affiliatedAuthor | Kim, Jae Jin | - |
dc.contributor.affiliatedAuthor | Rha, Dong Wook | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | NEUROIMAGE, Vol.34(1) : 19-25, 2007 | - |
dc.identifier.rimsid | 55225 | - |
dc.type.rims | ART | - |
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